Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 486067..486647 Replicon chromosome
Accession NZ_CP087042
Organism Pseudosulfitobacter pseudonitzschiae strain MC52-18

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE42_RS02495 Protein ID WP_224556587.1
Coordinates 486067..486321 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE42_RS02500 Protein ID WP_224556600.1
Coordinates 486318..486647 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE42_RS02450 (LOE42_02450) 481522..481770 + 249 WP_229940863.1 hypothetical protein -
LOE42_RS02455 (LOE42_02455) 482333..482875 + 543 WP_229940519.1 hypothetical protein -
LOE42_RS02460 (LOE42_02460) 483090..483413 + 324 WP_224556571.1 hypothetical protein -
LOE42_RS02465 (LOE42_02465) 483491..484006 - 516 WP_224556573.1 hypothetical protein -
LOE42_RS02470 (LOE42_02470) 483984..484811 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE42_RS02475 (LOE42_02475) 484808..484969 - 162 WP_224556578.1 hypothetical protein -
LOE42_RS02480 (LOE42_02480) 484969..485421 - 453 WP_224556581.1 hypothetical protein -
LOE42_RS02485 (LOE42_02485) 485497..485667 - 171 WP_224556583.1 hypothetical protein -
LOE42_RS02490 (LOE42_02490) 485767..485955 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE42_RS02495 (LOE42_02495) 486067..486321 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE42_RS02500 (LOE42_02500) 486318..486647 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE42_RS02505 (LOE42_02505) 486708..486971 + 264 WP_224556602.1 hypothetical protein -
LOE42_RS24510 486958..487080 - 123 WP_263481010.1 hypothetical protein -
LOE42_RS02510 (LOE42_02510) 487122..487376 - 255 WP_229997589.1 hypothetical protein -
LOE42_RS02515 (LOE42_02515) 487376..488263 - 888 WP_224556631.1 RNA ligase family protein -
LOE42_RS02520 (LOE42_02520) 488263..488625 - 363 WP_224556633.1 hypothetical protein -
LOE42_RS02525 (LOE42_02525) 488606..489352 - 747 WP_224556635.1 hypothetical protein -
LOE42_RS02530 (LOE42_02530) 489349..489576 - 228 WP_229940861.1 hypothetical protein -
LOE42_RS02535 (LOE42_02535) 490229..490666 - 438 WP_224556639.1 hypothetical protein -
LOE42_RS02540 (LOE42_02540) 490754..491185 - 432 WP_224556641.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 468375..502579 34204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224670 WP_224556587.1 NZ_CP087042:486067-486321 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224670 NZ_CP120393:4677818-4678129 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224670 WP_224556600.1 NZ_CP087042:486318-486647 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224670 NZ_CP120393:4678126-4678572 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References