Detailed information of TA system TA224669

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 887..1448
• Replicon: plasmid P9
• Accession: NZ_CP087041
• Organism: Pseudosulfitobacter pseudonitzschiae strain MC52-67

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOE43_RS24365
• Protein ID: WP_224557555.1
• Coordinates: 1173..1448 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOE43_RS24360
• Protein ID: WP_224557554.1
• Coordinates: 887..1180 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOE43_RS24360 (LOE43_24340)	887..1180	+	294	WP_224557554.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOE43_RS24365 (LOE43_24345)	1173..1448	+	276	WP_224557555.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOE43_RS24370 (LOE43_24350)	1917..2687	-	771	WP_224557557.1	GntR family transcriptional regulator	-
LOE43_RS24375 (LOE43_24355)	2779..4326	+	1548	WP_224557559.1	altronate dehydratase family protein	-
LOE43_RS24380 (LOE43_24360)	4343..5659	+	1317	WP_224557560.1	lactate racemase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..82231	82231

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-55)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10108.67 Da
• Isoelectric Point: 4.4912

>T224669 WP_224557555.1 NZ_CP087041:1173-1448 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Nucleotide

• Length: 276 bp

>T224669 NZ_CP120393:c4676356-4675982 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAAAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
CAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10166.59 Da
• Isoelectric Point: 7.2024

>AT224669 WP_224557554.1 NZ_CP087041:887-1180 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Nucleotide

• Length: 294 bp

>AT224669 NZ_CP120393:c4676598-4676356 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA