Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 69952..70626 Replicon plasmid P6
Accession NZ_CP087038
Organism Pseudosulfitobacter pseudonitzschiae strain MC52-67

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE43_RS23135 Protein ID WP_224557924.1
Coordinates 69952..70374 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE43_RS23140 Protein ID WP_229939240.1
Coordinates 70378..70626 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE43_RS23125 (LOE43_23120) 66150..67208 - 1059 WP_224557922.1 HEPN domain-containing protein -
LOE43_RS23130 (LOE43_23125) 67205..69955 - 2751 WP_224557923.1 lactate dehydrogenase -
LOE43_RS23135 (LOE43_23130) 69952..70374 - 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE43_RS23140 (LOE43_23135) 70378..70626 - 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE43_RS23145 (LOE43_23140) 70774..71763 - 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE43_RS23150 (LOE43_23145) 71874..73331 - 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE43_RS23155 (LOE43_23150) 73334..74065 - 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE43_RS23160 (LOE43_23155) 74069..74713 - 645 WP_224557929.1 type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..84803 84803


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224667 WP_224557924.1 NZ_CP087038:c70374-69952 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224667 NZ_CP120393:c4123925-4123437 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCGCCCCTGAACCGCTTCATGCCGGGCATATTCTTACCCCCTTCTGCTGCGGTGTGGATTCAATGGATAACTG
GCTAAAACAGCGGGCGATGAAAAATCAGGTAACTGGCGCATCCCGTACCTTTGTGTGTTGCGGCAGCGATTCTGACGTAC
TGGCGTATTATTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGTCGCTTTCGTCGCAATATGCCCGATCCG
ATCCCGGTTGTGGTGCTGGGCCGTCTGGCGGTGGATCGGTCGCTACATGGGCAGGGCGTAGGTCGGGCGCTGGTGAGGGA
TGCCGGGCTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTCCATGCCCTGTCGGATGAAGCGC
GGGAGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTT
CATGCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224667 WP_229939240.1 NZ_CP087038:c70626-70378 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224667 NZ_CP120393:c4124215-4123922 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGTCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCAAAAGCCAGAGGGAAAAACTGCACAGACTTTGTGCTAGAAGCTGCCCGCGCCGCCGCCGAGGAAGCGCTGA
TCGAGCAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGCATTTCTGATCCGTCTGGATCAGGCTCCTGCGCCAAAC
GATGCGTTGCGTAAAACCATGCAGACTCCTGCACCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References