Detailed information of TA system TA224664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2015901..2016481
• Replicon: chromosome
• Accession: NZ_CP087032
• Organism: Pseudosulfitobacter pseudonitzschiae strain MC52-67

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LOE43_RS10275
• Protein ID: WP_224556587.1
• Coordinates: 2016227..2016481 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LOE43_RS10270
• Protein ID: WP_224556600.1
• Coordinates: 2015901..2016230 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOE43_RS10230 (LOE43_10240)	2011603..2012172	+	570	WP_224556654.1	hypothetical protein	-
LOE43_RS10235 (LOE43_10245)	2012269..2012631	-	363	WP_224556648.1	type II toxin-antitoxin system HicB family antitoxin	-
LOE43_RS10240 (LOE43_10250)	2012890..2013525	-	636	WP_224556647.1	S24 family peptidase	-
LOE43_RS10245 (LOE43_10255)	2013612..2013812	+	201	WP_229940767.1	hypothetical protein	-
LOE43_RS10250 (LOE43_10260)	2013809..2014378	+	570	WP_229996405.1	phage minor head protein	-
LOE43_RS10255 (LOE43_10265)	2014598..2015122	+	525	WP_224556606.1	hypothetical protein	-
LOE43_RS10260 (LOE43_10270)	2015185..2015475	+	291	WP_224556604.1	hypothetical protein	-
LOE43_RS24720	2015468..2015590	+	123	WP_263481010.1	hypothetical protein	-
LOE43_RS10265 (LOE43_10275)	2015577..2015840	-	264	WP_224556602.1	hypothetical protein	-
LOE43_RS10270 (LOE43_10280)	2015901..2016230	-	330	WP_224556600.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LOE43_RS10275 (LOE43_10285)	2016227..2016481	-	255	WP_224556587.1	type II toxin-antitoxin system HicA family toxin	Toxin
LOE43_RS10280 (LOE43_10290)	2016593..2016781	-	189	WP_224556585.1	ribbon-helix-helix domain-containing protein	-
LOE43_RS10285 (LOE43_10295)	2016881..2017051	+	171	WP_224556583.1	hypothetical protein	-
LOE43_RS10290 (LOE43_10300)	2017127..2017579	+	453	WP_224556581.1	hypothetical protein	-
LOE43_RS10295 (LOE43_10305)	2017579..2017740	+	162	WP_224556578.1	hypothetical protein	-
LOE43_RS10300 (LOE43_10310)	2017737..2018564	+	828	WP_224556575.1	ParB N-terminal domain-containing protein	-
LOE43_RS10305 (LOE43_10315)	2018542..2019057	+	516	WP_224556573.1	hypothetical protein	-
LOE43_RS10310 (LOE43_10320)	2019135..2019458	-	324	WP_224556571.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2004527..2034721	30194

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (25-82)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9336.69 Da
• Isoelectric Point: 10.8025

>T224664 WP_224556587.1 NZ_CP087032:c2016481-2016227 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Nucleotide

• Length: 255 bp

>T224664 NZ_CP120393:c2773900-2773798 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12090.66 Da
• Isoelectric Point: 6.0876

>AT224664 WP_224556600.1 NZ_CP087032:c2016230-2015901 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Nucleotide

• Length: 330 bp

>AT224664 NZ_CP120393:2773796-2773939 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG