Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 43940..44405 Replicon chromosome
Accession NZ_CP087032
Organism Pseudosulfitobacter pseudonitzschiae strain MC52-67

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE43_RS00225 Protein ID WP_224557762.1
Coordinates 44142..44405 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE43_RS00220 Protein ID WP_224557764.1
Coordinates 43940..44155 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE43_RS00185 (LOE43_00185) 39048..39413 + 366 WP_028957811.1 cytochrome o ubiquinol oxidase subunit IV -
LOE43_RS00190 (LOE43_00190) 39410..40108 + 699 WP_037931342.1 SURF1 family protein -
LOE43_RS00200 (LOE43_00200) 40486..41670 + 1185 WP_224557768.1 site-specific integrase -
LOE43_RS00205 (LOE43_00205) 41663..42634 + 972 WP_224557767.1 hypothetical protein -
LOE43_RS00210 (LOE43_00210) 42815..43195 + 381 WP_224557766.1 helix-turn-helix domain-containing protein -
LOE43_RS00215 (LOE43_00215) 43363..43587 + 225 WP_224557765.1 hypothetical protein -
LOE43_RS00220 (LOE43_00220) 43940..44155 - 216 WP_224557764.1 CopG family antitoxin Antitoxin
LOE43_RS00225 (LOE43_00225) 44142..44405 - 264 WP_224557762.1 BrnT family toxin Toxin
LOE43_RS00230 (LOE43_00230) 44593..45036 + 444 WP_224557760.1 hypothetical protein -
LOE43_RS00235 (LOE43_00235) 45129..46237 + 1109 Protein_39 IS110 family transposase -
LOE43_RS00240 (LOE43_00240) 46463..46951 + 489 WP_229938596.1 DEAD/DEAH box helicase family protein -
LOE43_RS00245 (LOE43_00245) 46875..47141 + 267 WP_229938971.1 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -
LOE43_RS00250 (LOE43_00250) 47138..48688 + 1551 WP_224557015.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10254.52 Da        Isoelectric Point: 5.6550

>T224663 WP_224557762.1 NZ_CP087032:c44405-44142 [Pseudosulfitobacter pseudonitzschiae]
MKFEYDPDKSAGNKAKHGIDFDEAQALWEDPWLLEAPARTDDEPRFFAIGMIKERHWSAVCTYRGDIIRIISVRRARKQE
IEHYEST

Download         Length: 264 bp

>T224663 NZ_CP120393:c1404432-1404214 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8265.40 Da        Isoelectric Point: 10.6538

>AT224663 WP_224557764.1 NZ_CP087032:c44155-43940 [Pseudosulfitobacter pseudonitzschiae]
MKAREFDQKFDTGENVSDLVDWSKARRTNTQTKRVNVDFPSWVVSGLDQKAKQLGVTRQSLIKLWIAERLQ

Download         Length: 216 bp

>AT224663 NZ_CP120393:c1404834-1404460 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References