Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 79984..80658 Replicon plasmid P2
Accession NZ_CP087018
Organism Pseudosulfitobacter pseudonitzschiae strain MC52-70

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE45_RS19955 Protein ID WP_224557924.1
Coordinates 79984..80406 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE45_RS19960 Protein ID WP_229939240.1
Coordinates 80410..80658 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE45_RS19945 (LOE45_19955) 76182..77240 - 1059 WP_224557922.1 HEPN domain-containing protein -
LOE45_RS19950 (LOE45_19960) 77237..79987 - 2751 WP_224557923.1 lactate dehydrogenase -
LOE45_RS19955 (LOE45_19965) 79984..80406 - 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE45_RS19960 (LOE45_19970) 80410..80658 - 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE45_RS19965 (LOE45_19975) 80806..81795 - 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE45_RS19970 (LOE45_19980) 81906..83363 - 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE45_RS19975 (LOE45_19985) 83366..84097 - 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE45_RS19980 (LOE45_19990) 84101..84745 - 645 WP_224557929.1 type IV secretion system protein -
LOE45_RS19985 (LOE45_19995) 84748..85375 - 628 WP_229992502.1 type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..85375 85375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224655 WP_224557924.1 NZ_CP087018:c80406-79984 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224655 NZ_CP120392:c4126196-4125708 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCGCCCCTGAACCGCTTCATGCCGGGCATATTCTTACCCCCTTCTGCTGCGGTGTGGATTCAATGGATAACTG
GCTAAAACAGCGGGCGATGAAAAATCAGGTAACTGGCGCATCCCGTACCTTTGTGTGTTGCGGCAGCGATTCTGACGTAC
TGGCGTATTATTCGCTGGCGTCCAGCGCGGTAACGACAAACACCGCCCCCGGTCGCTTTCGTCGCAATATGCCCGATCCG
ATCCCGGTTGTGGTGCTGGGCCGTCTGGCGGTGGATCGGTCGCTACATGGGCAGGGCGTAGGTCGGGCGCTGGTGAGGGA
TGCCGGGCTGCGGGTGATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGCTGGTCCATGCCCTGTCGGATGAAGCGC
GGGAGTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTT
CATGCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224655 WP_229939240.1 NZ_CP087018:c80658-80410 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224655 NZ_CP120392:c4126486-4126193 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGTCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAGCCCGCCGAGCGCGATCTTATCGA
TCGGGCTGCAAAAGCCAGAGGGAAAAACTGCACAGACTTTGTGCTAGAAGCTGCCCGCGCCGCCGCCGAGGAAGCGCTGA
TCGAGCAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGCATTTCTGATCCGTCTGGATCAGGCTCCTGCGCCAAAC
GATGCGTTGCGTAAAACCATGCAGACTCCTGCACCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References