Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1335002..1335582 Replicon chromosome
Accession NZ_CP087016
Organism Pseudosulfitobacter pseudonitzschiae strain MC52-70

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE45_RS07005 Protein ID WP_224556587.1
Coordinates 1335328..1335582 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE45_RS07000 Protein ID WP_224556600.1
Coordinates 1335002..1335331 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE45_RS06955 (LOE45_06960) 1330069..1330704 - 636 WP_224556647.1 S24 family peptidase -
LOE45_RS06960 (LOE45_06965) 1330794..1330991 + 198 WP_224556645.1 hypothetical protein -
LOE45_RS06965 (LOE45_06970) 1330988..1331656 + 669 WP_224556642.1 hypothetical protein -
LOE45_RS06970 (LOE45_06975) 1331660..1332091 + 432 WP_224556641.1 hypothetical protein -
LOE45_RS06975 (LOE45_06980) 1332179..1332619 + 441 WP_229992456.1 hypothetical protein -
LOE45_RS06980 (LOE45_06985) 1332556..1333479 + 924 WP_229940510.1 phage minor head protein -
LOE45_RS06985 (LOE45_06990) 1333699..1334223 + 525 WP_224556606.1 hypothetical protein -
LOE45_RS06990 (LOE45_06995) 1334286..1334576 + 291 WP_224556604.1 hypothetical protein -
LOE45_RS23300 1334569..1334691 + 123 WP_263481010.1 hypothetical protein -
LOE45_RS06995 (LOE45_07000) 1334678..1334941 - 264 WP_224556602.1 hypothetical protein -
LOE45_RS07000 (LOE45_07005) 1335002..1335331 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE45_RS07005 (LOE45_07010) 1335328..1335582 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE45_RS07010 (LOE45_07015) 1335694..1335882 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE45_RS07015 (LOE45_07020) 1335982..1336152 + 171 WP_224556583.1 hypothetical protein -
LOE45_RS07020 (LOE45_07025) 1336228..1336680 + 453 WP_224556581.1 hypothetical protein -
LOE45_RS07025 (LOE45_07030) 1336680..1336841 + 162 WP_224556578.1 hypothetical protein -
LOE45_RS07030 (LOE45_07035) 1336838..1337665 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE45_RS07035 (LOE45_07040) 1337643..1337855 + 213 WP_229992459.1 hypothetical protein -
LOE45_RS07040 (LOE45_07045) 1337870..1340062 + 2193 WP_229992461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1321706..1349926 28220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224653 WP_224556587.1 NZ_CP087016:c1335582-1335328 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224653 NZ_CP120392:c3906610-3906323 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224653 WP_224556600.1 NZ_CP087016:c1335331-1335002 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224653 NZ_CP120392:c3906336-3906034 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References