Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 86239..86913 Replicon plasmid P1
Accession NZ_CP087010
Organism Pseudosulfitobacter pseudonitzschiae strain MC52-71

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE46_RS19670 Protein ID WP_224557924.1
Coordinates 86239..86661 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE46_RS19675 Protein ID WP_229939240.1
Coordinates 86665..86913 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE46_RS19660 (LOE46_19665) 82437..83495 - 1059 WP_224557922.1 HEPN domain-containing protein -
LOE46_RS19665 (LOE46_19670) 83492..86242 - 2751 WP_224557923.1 lactate dehydrogenase -
LOE46_RS19670 (LOE46_19675) 86239..86661 - 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE46_RS19675 (LOE46_19680) 86665..86913 - 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE46_RS19680 (LOE46_19685) 87061..88050 - 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE46_RS19685 (LOE46_19690) 88161..89618 - 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE46_RS19690 (LOE46_19695) 89621..90352 - 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE46_RS19695 (LOE46_19700) 90356..91000 - 645 WP_224557929.1 type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..157665 157665


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224649 WP_224557924.1 NZ_CP087010:c86661-86239 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224649 NZ_CP120392:820736-821134 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224649 WP_229939240.1 NZ_CP087010:c86913-86665 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224649 NZ_CP120392:820509-820736 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References