Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2523581..2524161 Replicon chromosome
Accession NZ_CP087009
Organism Pseudosulfitobacter pseudonitzschiae strain MC52-71

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE46_RS12670 Protein ID WP_224556587.1
Coordinates 2523907..2524161 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE46_RS12665 Protein ID WP_224556600.1
Coordinates 2523581..2523910 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE46_RS12610 (LOE46_12620) 2518653..2519543 + 891 WP_229940766.1 RNA ligase family protein -
LOE46_RS12615 (LOE46_12625) 2519543..2519731 + 189 WP_224556628.1 hypothetical protein -
LOE46_RS12620 (LOE46_12630) 2519728..2519886 + 159 WP_224556625.1 hypothetical protein -
LOE46_RS12625 (LOE46_12635) 2519883..2520137 + 255 WP_224556623.1 hypothetical protein -
LOE46_RS12630 (LOE46_12640) 2520134..2520439 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE46_RS12635 (LOE46_12645) 2520436..2520852 + 417 WP_229940505.1 hypothetical protein -
LOE46_RS12640 (LOE46_12650) 2520849..2521013 + 165 WP_229940508.1 hypothetical protein -
LOE46_RS12645 (LOE46_12655) 2521135..2522058 + 924 WP_229940510.1 phage minor head protein -
LOE46_RS12650 (LOE46_12660) 2522278..2522802 + 525 WP_224556606.1 hypothetical protein -
LOE46_RS12655 (LOE46_12665) 2522865..2523155 + 291 WP_224556604.1 hypothetical protein -
LOE46_RS23740 2523148..2523270 + 123 WP_263481010.1 hypothetical protein -
LOE46_RS12660 (LOE46_12670) 2523257..2523520 - 264 WP_224556602.1 hypothetical protein -
LOE46_RS12665 (LOE46_12675) 2523581..2523910 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE46_RS12670 (LOE46_12680) 2523907..2524161 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE46_RS12675 (LOE46_12685) 2524273..2524461 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE46_RS12680 (LOE46_12690) 2524561..2524731 + 171 WP_224556583.1 hypothetical protein -
LOE46_RS12685 (LOE46_12695) 2524807..2525259 + 453 WP_224556581.1 hypothetical protein -
LOE46_RS12690 (LOE46_12700) 2525259..2525420 + 162 WP_224556578.1 hypothetical protein -
LOE46_RS12695 (LOE46_12705) 2525417..2526244 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE46_RS12700 (LOE46_12710) 2526222..2526737 + 516 WP_224556573.1 hypothetical protein -
LOE46_RS12705 (LOE46_12715) 2526815..2527138 - 324 WP_224556571.1 hypothetical protein -
LOE46_RS12710 (LOE46_12720) 2527353..2527895 - 543 WP_229940519.1 hypothetical protein -
LOE46_RS12715 (LOE46_12725) 2528458..2528706 - 249 WP_229940863.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2505780..2542401 36621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224648 WP_224556587.1 NZ_CP087009:c2524161-2523907 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224648 NZ_CP120392:803991-804392 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCCTTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGACAG
GACTGGACGCTCTTGCGTCCTCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
AG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224648 WP_224556600.1 NZ_CP087009:c2523910-2523581 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224648 NZ_CP120392:803744-804010 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References