Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 7192..7804 Replicon plasmid P3
Accession NZ_CP087005
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-105

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE06_RS21560 Protein ID WP_028288627.1
Coordinates 7192..7587 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE06_RS21565 Protein ID WP_009503866.1
Coordinates 7577..7804 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE06_RS21540 (LOE06_21510) 3711..4322 - 612 WP_197919471.1 SMC-Scp complex subunit ScpB -
LOE06_RS21545 (LOE06_21515) 4370..5254 - 885 WP_037239259.1 DUF1403 family protein -
LOE06_RS21550 (LOE06_21520) 5369..6520 + 1152 WP_224557873.1 tyrosine-type recombinase/integrase -
LOE06_RS21555 (LOE06_21525) 6622..7113 + 492 Protein_5 recombinase family protein -
LOE06_RS21560 (LOE06_21530) 7192..7587 - 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE06_RS21565 (LOE06_21535) 7577..7804 - 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE06_RS21570 (LOE06_21540) 8013..9206 + 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE06_RS21575 (LOE06_21545) 9190..10122 + 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE06_RS21580 (LOE06_21550) 10336..11547 + 1212 WP_050525470.1 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..111866 111866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224644 WP_028288627.1 NZ_CP087005:c7587-7192 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224644 NZ_CP120376:c5864881-5864540 [Pseudomonas nitroreducens]
ATGACAGTACGCGAGATCCGCTTCACTGAAACGGCAGTCTTCAGCATTCAGGACCAGGAAGAACACCTGGCCGAGTACCA
TCCTCCCGAACTTGCTGCTGTAAAGATCGATGGCTTGATCGATGAGATACTGACCAGGCTGCAGAACGCTCCCGTGGGCT
ACCCCGTCAGCCGCCAGGCCACCGACCTGGGAGTGACCCGTTACCGGGAACTCAACCACGACGGATACCGTGTGTTCTAC
GAGGTCTACGAGCACGACAACGTGATTGCCGTCGAACTGGTCCTGCGCCAGAAGCAGGACGTCGAAGCAGCCCTGATCCG
CTACTGCCTGGTTGGTATCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224644 WP_009503866.1 NZ_CP087005:c7804-7577 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224644 NZ_CP120376:c5865136-5864888 [Pseudomonas nitroreducens]
GTGCGCGTTGAAACGATCAGCTACCTCAAGCGGCATGCCGCAGATCTCGACCTGGACGAACCAATGGTCGTCACCCAGAA
CGGCGTACCCACCCTGGTGGTGGAGTCCTACGCCGAGCGTAAGCGCCGCGACCAGGCTATCGCCCTGGTCAAGCTGCTTG
CCATGGGATCGCGCGAGTACGCCGAAGGCAAGCACTGCTCTGTAGACGAGCTGAAGGCCCGCCTGGCCAAGCGACGTAGC
CAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References