Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 24883..25495 Replicon plasmid P6
Accession NZ_CP087001
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-109

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE07_RS23875 Protein ID WP_028288627.1
Coordinates 24883..25278 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE07_RS23880 Protein ID WP_009503866.1
Coordinates 25268..25495 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE07_RS23855 (LOE07_23830) 21402..22013 - 612 WP_197919471.1 SMC-Scp complex subunit ScpB -
LOE07_RS23860 (LOE07_23835) 22061..22945 - 885 WP_229997756.1 DUF1403 family protein -
LOE07_RS23865 (LOE07_23840) 23060..24211 + 1152 WP_224557873.1 tyrosine-type recombinase/integrase -
LOE07_RS23870 (LOE07_23845) 24313..24804 + 492 Protein_23 recombinase family protein -
LOE07_RS23875 (LOE07_23850) 24883..25278 - 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE07_RS23880 (LOE07_23855) 25268..25495 - 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE07_RS23885 (LOE07_23860) 25704..26897 + 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE07_RS23890 (LOE07_23865) 26881..27813 + 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE07_RS23895 (LOE07_23870) 28027..29238 + 1212 WP_050525470.1 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..111866 111866


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224640 WP_028288627.1 NZ_CP087001:c25278-24883 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224640 NZ_CP120376:c2599099-2598665 [Pseudomonas nitroreducens]
GTGGCCACGCCCGTCACCTATATGCTGGATACCAACATCTGCTCCTTCATCATGCGCCAGAACCCACCCCAGGTTTTGCA
GCGTCTGCAAAAGGCCGCGGAGTCCGGCAACAGGCTGGTGATTTCGGCTATCACTCATGCGGAGCTTCGTTACGGCGCAG
CGTCACCGAAAGCCCCGAAGGCGGTGGCAGCATGGATCGACGCATTGGTGCAACGCCTGGACGATGTGCTGCCCTGGGAT
ATCGACGCGGTGGATAGCTCCGCGAAGCTCATGAGTCTCCTGCTCGACTCAGGAACGCCCATTGGGCCGAACGATACGGG
CATTGCCAGCCATGCCTTGGCAACCGATTGCGTCATCGTGACCAACAACACCCGCGAATTTCGGCGAGTACCGGGGCTTG
TCGTCGAAGACTGGTGCAACAGCGAACCGGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224640 WP_009503866.1 NZ_CP087001:c25495-25268 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224640 NZ_CP120376:c2599376-2599104 [Pseudomonas nitroreducens]
ATGCTCTCTGATCTGGAGGCGCCCACGCCCACGACGACCGTTTCCTTGTTCCGCAACGGCAAGAATCAGGCAGTCCGAAT
CCCTCGGGATATGGAATTCAAGGGAGTGACGGAACTGGTGATGACTCGCGAAGGCGATACGCTCATCCTGCGCCCGTCGC
GGCCCACCTGGAGCAGCCTCGCCGAGCTGGAACCTGTCGATGCCGATTTTCTGGGAGATCGGCCCGACGTGATTGCCCCC
AGCCGGTTGGGCTTCGGCGATGACGAGGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References