Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2021601..2022181 Replicon chromosome
Accession NZ_CP086995
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-109

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE07_RS10340 Protein ID WP_224556587.1
Coordinates 2021927..2022181 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE07_RS10335 Protein ID WP_224556600.1
Coordinates 2021601..2021930 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE07_RS10280 (LOE07_10270) 2017035..2017397 + 363 WP_224556633.1 hypothetical protein -
LOE07_RS10285 (LOE07_10275) 2017397..2018284 + 888 WP_224556631.1 RNA ligase family protein -
LOE07_RS10290 (LOE07_10280) 2018284..2018472 + 189 WP_224556628.1 hypothetical protein -
LOE07_RS10295 (LOE07_10285) 2018469..2018627 + 159 WP_224556625.1 hypothetical protein -
LOE07_RS10300 (LOE07_10290) 2018624..2018878 + 255 WP_224556623.1 hypothetical protein -
LOE07_RS10305 (LOE07_10295) 2018875..2019180 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE07_RS10310 (LOE07_10300) 2019177..2019593 + 417 WP_229940505.1 hypothetical protein -
LOE07_RS10315 (LOE07_10305) 2019590..2019754 + 165 WP_229940508.1 hypothetical protein -
LOE07_RS10320 (LOE07_10310) 2020298..2020822 + 525 WP_224556606.1 hypothetical protein -
LOE07_RS10325 (LOE07_10315) 2020885..2021175 + 291 WP_224556604.1 hypothetical protein -
LOE07_RS24340 2021168..2021290 + 123 WP_263481010.1 hypothetical protein -
LOE07_RS10330 (LOE07_10320) 2021277..2021540 - 264 WP_224556602.1 hypothetical protein -
LOE07_RS10335 (LOE07_10325) 2021601..2021930 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE07_RS10340 (LOE07_10330) 2021927..2022181 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE07_RS10345 (LOE07_10335) 2022293..2022481 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE07_RS10350 (LOE07_10340) 2022581..2022751 + 171 WP_224556583.1 hypothetical protein -
LOE07_RS10355 (LOE07_10345) 2022827..2023279 + 453 WP_224556581.1 hypothetical protein -
LOE07_RS10360 (LOE07_10350) 2023279..2023440 + 162 WP_224556578.1 hypothetical protein -
LOE07_RS10365 (LOE07_10355) 2023437..2024264 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE07_RS10370 (LOE07_10360) 2024242..2024757 + 516 WP_224556573.1 hypothetical protein -
LOE07_RS10375 (LOE07_10365) 2024835..2025158 - 324 WP_224556571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2004521..2040421 35900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224635 WP_224556587.1 NZ_CP086995:c2022181-2021927 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224635 NZ_CP120374:c1269543-1269052 [Sinorhizobium garamanticum]
ATGCCGCTCTGGCGCGCCTTCGTGCCGCGCTGGGCTCATGCCCCGCTTTCCGGCGAAGGTGCGGCGCGTTTCGGCGGCCG
ATGGAACCCGGTGGGCGTGCCGACGATCTATGCCGCGCGCGAACTTTCGACCGCCTGGGCCGAATACAATCAGGGTTTCG
TGCAGCATCCGGCGCTGATCGTACGGCTCGAGCTTTACGATGCGCGGCTGGCCGATCTCACGGACGCCAATGTTCTTGCG
GAGCTTGGCCTGACGGATGCCATCCACCGATGCGAGTGGCGAGACGACCTCGACAAGGGCGTGGTGCCGCAGACCCATGA
GGTGCAGGCCGATCTCCTGGCCCAGGAATTTCACGGCGTGATCTACCCGTCATTCATGTCGCCCGGCGGCACCTGCGTCG
CACTCTGGCGCTGGAACGGCGCGGGTGCGCCACGCCTCGAGGTCATCGATCCCGAAGGCAGGCTGCCGAAGTCGCCGGCC
TCCTGGGTTTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224635 WP_224556600.1 NZ_CP086995:c2021930-2021601 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224635 NZ_CP120374:c1269982-1269611 [Sinorhizobium garamanticum]
ATGGTCGCCCTCAATCTGGACATTCCCGCCGCCCGCTTCGGGGAGGATCATTCCCCGTTCCTGTCGGCGCGCCTTGTTGC
CGACCGTCTGGGCATAACGCTTGCCGAACTCGCCAAGCTGATCGGCGTCGCGCGGAACACGCTGACAGCCAAGACCGGCG
CCCGCAAGGTCGATAGCGCCCTGAGCAATGTCGTCCGCATCCTCTCCATGGCGTCCGAAATGGCGGGCGACGAGGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCGATCCCCGGCTGGGCCGGAAAGACGGCGTTCGATCTCGTCGGCGAAGGCAAGGC
CGACAAGGTTCTCGCTTATCTGGAAGCTGTTCGCGCCGGCGTCTACGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References