Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2515752..2516332 Replicon chromosome
Accession NZ_CP086986
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-110

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE08_RS12220 Protein ID WP_224556587.1
Coordinates 2515752..2516006 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE08_RS12225 Protein ID WP_224556600.1
Coordinates 2516003..2516332 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE08_RS12185 (LOE08_12170) 2512775..2513098 + 324 WP_224556571.1 hypothetical protein -
LOE08_RS12190 (LOE08_12175) 2513176..2513691 - 516 WP_224556573.1 hypothetical protein -
LOE08_RS12195 (LOE08_12180) 2513669..2514496 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE08_RS12200 (LOE08_12185) 2514493..2514654 - 162 WP_224556578.1 hypothetical protein -
LOE08_RS12205 (LOE08_12190) 2514654..2515106 - 453 WP_224556581.1 hypothetical protein -
LOE08_RS12210 (LOE08_12195) 2515182..2515352 - 171 WP_224556583.1 hypothetical protein -
LOE08_RS12215 (LOE08_12200) 2515452..2515640 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE08_RS12220 (LOE08_12205) 2515752..2516006 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE08_RS12225 (LOE08_12210) 2516003..2516332 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE08_RS12230 (LOE08_12215) 2516393..2516656 + 264 WP_224556602.1 hypothetical protein -
LOE08_RS24700 2516643..2516765 - 123 WP_263481010.1 hypothetical protein -
LOE08_RS12235 (LOE08_12220) 2516758..2517048 - 291 WP_224556604.1 hypothetical protein -
LOE08_RS12240 (LOE08_12225) 2517111..2517635 - 525 WP_224556606.1 hypothetical protein -
LOE08_RS12245 (LOE08_12230) 2518179..2518343 - 165 WP_229940508.1 hypothetical protein -
LOE08_RS12250 (LOE08_12235) 2518340..2518756 - 417 WP_229940505.1 hypothetical protein -
LOE08_RS12255 (LOE08_12240) 2518753..2519058 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE08_RS12260 (LOE08_12245) 2519055..2519309 - 255 WP_224556623.1 hypothetical protein -
LOE08_RS12265 (LOE08_12250) 2519306..2519464 - 159 WP_224556625.1 hypothetical protein -
LOE08_RS12270 (LOE08_12255) 2519461..2519649 - 189 WP_224556628.1 hypothetical protein -
LOE08_RS12275 (LOE08_12260) 2519649..2520536 - 888 WP_224556631.1 RNA ligase family protein -
LOE08_RS12280 (LOE08_12265) 2520536..2520898 - 363 WP_224556633.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2498060..2534852 36792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224630 WP_224556587.1 NZ_CP086986:2515752-2516006 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224630 NZ_CP120370:c587206-586769 [Sinorhizobium numidicum]
GTGACTTTCCTGCTCGACGTCAATGTGCTGATCGCCTTAATCGATCCGGGCCATGTAGCCCATGATGACGCGCACGATTG
GTTCGCATCGATCGGCCAGACCGCGTGGGCTACCTGCCCCATTACTGAAAATGGTGTCATCCGGATCGTGGGCAACGCCA
AGTATCCCAACTCTCCCGGCTCACCGTCACTCGTGATGGAGATCGTTGGCAAATTGCGGTCGCTACCCGGTCACTGTTTT
TGGCCGGACGATGTGAGCCTCGTCGGGTCAGGTGATATCGCTGCCACGAAAATCCTAACTTCGGGGCAGGTAACGGACAC
CTATCTGCTTGCACTCGCGAAGGCGCATGGGGGCCAGTTGGCGACATTCGATCGCAAGCTGTCAGCAGCGGCGGTCACAA
GGGGCAATGCTGCCTTGCGCCTGATCACCAGCAAATAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224630 WP_224556600.1 NZ_CP086986:2516003-2516332 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224630 NZ_CP120370:c587430-587203 [Sinorhizobium numidicum]
ATGAGAACGACACTGGCGATCGATGACGATGTCCTGATCGCCGCCAAAGCGATGGCAGCCCAGCAGCACCGTAGTGTCGG
CGAGGTCATTTCCGAACTGGCGAGGCGTTCTCTGCGCCGGCCTCGCAGCGGCGGCGAGCGCAATGGAATTCCTCTTCTGT
CACCTCGGCCGGACGCGCCGCCAGTGACTCTCGAGATCGTCAACGCCTTGCGTGACGAACTGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References