Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3423207..3424042 | Replicon | chromosome |
| Accession | NC_009801 | ||
| Organism | Escherichia coli E24377A | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A7ZRI1 |
| Locus tag | ECE24377A_RS18690 | Protein ID | WP_000854738.1 |
| Coordinates | 3423665..3424042 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A7ZRI0 |
| Locus tag | ECE24377A_RS18685 | Protein ID | WP_012139188.1 |
| Coordinates | 3423207..3423575 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECE24377A_RS18650 | 3419098..3419778 | + | 681 | WP_001282919.1 | WYL domain-containing protein | - |
| ECE24377A_RS18655 | 3419926..3420603 | + | 678 | WP_001097300.1 | hypothetical protein | - |
| ECE24377A_RS18660 | 3420609..3420842 | + | 234 | WP_001278282.1 | DUF905 family protein | - |
| ECE24377A_RS18665 | 3420932..3421750 | + | 819 | WP_001234690.1 | DUF945 domain-containing protein | - |
| ECE24377A_RS18670 | 3421842..3422327 | + | 486 | WP_000213725.1 | antirestriction protein | - |
| ECE24377A_RS18675 | 3422343..3422819 | + | 477 | WP_001186781.1 | RadC family protein | - |
| ECE24377A_RS18680 | 3422906..3423127 | + | 222 | WP_000692348.1 | DUF987 domain-containing protein | - |
| ECE24377A_RS18685 | 3423207..3423575 | + | 369 | WP_012139188.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| ECE24377A_RS18690 | 3423665..3424042 | + | 378 | WP_000854738.1 | TA system toxin CbtA family protein | Toxin |
| ECE24377A_RS18695 | 3424039..3424527 | + | 489 | WP_000761672.1 | hypothetical protein | - |
| ECE24377A_RS18700 | 3424539..3424736 | + | 198 | WP_000839234.1 | DUF957 domain-containing protein | - |
| ECE24377A_RS18705 | 3424821..3425666 | + | 846 | WP_000065749.1 | DUF4942 domain-containing protein | - |
| ECE24377A_RS18710 | 3425735..3426130 | + | 396 | WP_000208385.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| ECE24377A_RS18715 | 3426123..3427070 | + | 948 | WP_012139193.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| ECE24377A_RS18720 | 3427425..3427961 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC / rfaE | 3348871..3530406 | 181535 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14089.12 Da Isoelectric Point: 8.2904
>T22463 WP_000854738.1 NC_009801:3423665-3424042 [Escherichia coli O139:H28 str. E24377A]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMVRDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMVRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T22463 NC_009801:3423665-3424042 [Escherichia coli O139:H28 str. E24377A]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGGTCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGGTCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13582.31 Da Isoelectric Point: 6.2035
>AT22463 WP_012139188.1 NC_009801:3423207-3423575 [Escherichia coli O139:H28 str. E24377A]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT22463 NC_009801:3423207-3423575 [Escherichia coli O139:H28 str. E24377A]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCGGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|