Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 19373..19985 Replicon plasmid P4
Accession NZ_CP086975
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-114

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE10_RS22565 Protein ID WP_028288627.1
Coordinates 19590..19985 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE10_RS22560 Protein ID WP_009503866.1
Coordinates 19373..19600 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE10_RS22545 (LOE10_22530) 15630..16841 - 1212 WP_050525470.1 plasmid replication protein RepC -
LOE10_RS22550 (LOE10_22535) 17055..17987 - 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE10_RS22555 (LOE10_22540) 17971..19164 - 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE10_RS22560 (LOE10_22545) 19373..19600 + 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE10_RS22565 (LOE10_22550) 19590..19985 + 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE10_RS22570 (LOE10_22555) 20064..20555 - 492 Protein_22 recombinase family protein -
LOE10_RS22575 (LOE10_22560) 20657..21796 - 1140 WP_229940649.1 tyrosine-type recombinase/integrase -
LOE10_RS22580 (LOE10_22565) 21923..22807 + 885 WP_037239259.1 DUF1403 family protein -
LOE10_RS22585 (LOE10_22570) 22855..23466 + 612 WP_197919471.1 SMC-Scp complex subunit ScpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110568 110568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224621 WP_028288627.1 NZ_CP086975:19590-19985 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224621 NZ_CP120366:c932741-932358 [Sinorhizobium kummerowiae]
GTGATTCTTGCCGACACTTCAATCTGGATTGATCATTTCCGGCATACCGATGCCGAGCTGCGTAGGATTATTGAGGACGA
TCGTCTCCTCTGCCATCCGGCCGTGATCGGAGAGCTTGCACTTGGCAGCCTTCGGGAACGCAGTAGCGTGATAGCATTCC
TGATGGCTCAGCGCGAAGCACTCGTCGCAACGCACCAGGAGGTCATGATGATGATCGATCGCCACGCCATTTTTAGCATG
GGGATTGGCTACACGGATGCCCATTTGCTGGCCTCGGTTCTCCTCGATCAGCGAATGGCTTTGTGGACGAGAGACAAGCG
TTTGCAGGCAGCGGCCGAAAAGGCGGGGGCGTCGCTGCACACCCCCGCCCATACGCGGAACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224621 WP_009503866.1 NZ_CP086975:19373-19600 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224621 NZ_CP120366:c932938-932738 [Sinorhizobium kummerowiae]
ATGCGATCGACTATCAACCTCGACGACACTCTCATGGAAAGGGCTAAGTCCCTAACCGGCACAAAAGAAACCGCCGCTCT
GGTCCGCCAGGCATTGGAGACGCTTGTTCGTGTGGAGTCAGGAAAACGCCTCATCGCGCTCGGGGGAACTATGCCGGATG
CGGAAGCAGCTCCACGCCGCCGGAGCGCAGCTGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References