Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 90583..91195 Replicon plasmid P1
Accession NZ_CP086955
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-27

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE13_RS19710 Protein ID WP_028288627.1
Coordinates 90583..90978 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE13_RS19715 Protein ID WP_009503866.1
Coordinates 90968..91195 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE13_RS19690 (LOE13_19685) 87102..87713 - 612 WP_197919471.1 SMC-Scp complex subunit ScpB -
LOE13_RS19695 (LOE13_19690) 87761..88645 - 885 WP_037239259.1 DUF1403 family protein -
LOE13_RS19700 (LOE13_19695) 88772..89911 + 1140 WP_229940649.1 tyrosine-type recombinase/integrase -
LOE13_RS19705 (LOE13_19700) 90013..90504 + 492 Protein_92 recombinase family protein -
LOE13_RS19710 (LOE13_19705) 90583..90978 - 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE13_RS19715 (LOE13_19710) 90968..91195 - 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE13_RS19720 (LOE13_19715) 91404..92597 + 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE13_RS19725 (LOE13_19720) 92581..93513 + 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE13_RS19730 (LOE13_19725) 93727..94938 + 1212 WP_050525470.1 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110567 110567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224604 WP_028288627.1 NZ_CP086955:c90978-90583 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224604 NZ_CP120364:575836-576159 [Sinorhizobium kummerowiae]
ATGAGGCGTGGCGATCTCGTTACCGTCGCCATGCCGGGGGACTTCGGGAAGCCCCGGCCCGCCCTCATCATCCAGGCTGA
TTTGTTCGAGGACACCGGCACGGTGACGGTGCTGCTGGTGTCGGAAGCGTTGCTGGATGCCCCTCTGTTGCGGCCTACTG
TTCGACCGACGCGGGAGAATGGGCTTCGTAAACCGTCACAGATAATGATCGACAAGGCCATGCCGGTGAAACGAGATAAA
CTCGGCCCGCCCTTCGGCCGACTCGACGACCAAATGATGCTTTCCGTCGCTCGCTCGCTGGCCGTCTTCCTTGGTCTTGC
CTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224604 WP_009503866.1 NZ_CP086955:c91195-90968 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224604 NZ_CP120364:575621-575839 [Sinorhizobium kummerowiae]
ATGCCGACGCCTGTCACTCAACGGGTGCAAAAGCGCCGAGACGCGCTGCGGGCGGCTGGGTTGCGCCCCGTGCAAATATG
GGTTCCGGATACACGCCGACCCGGTTTTGCCGACGAGTGCCGTCGCCAGGCGGAGGCGGTCGCTGCGGCTGATGCTGCCG
ACCGCGATCTGGATGCCTTCATTGACGCCGCTCTGTCCGATCCCGACGGCGATGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References