Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 1833969..1834549 | Replicon | chromosome |
| Accession | NZ_CP086954 | ||
| Organism | Pseudosulfitobacter pseudonitzschiae strain SC1-27 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LOE13_RS08935 | Protein ID | WP_224556587.1 |
| Coordinates | 1833969..1834223 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LOE13_RS08940 | Protein ID | WP_224556600.1 |
| Coordinates | 1834220..1834549 (+) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOE13_RS08900 (LOE13_08895) | 1830938..1831315 | + | 378 | WP_229940765.1 | hypothetical protein | - |
| LOE13_RS08905 (LOE13_08900) | 1831393..1831908 | - | 516 | WP_224556573.1 | hypothetical protein | - |
| LOE13_RS08910 (LOE13_08905) | 1831886..1832713 | - | 828 | WP_224556575.1 | ParB N-terminal domain-containing protein | - |
| LOE13_RS08915 (LOE13_08910) | 1832710..1832871 | - | 162 | WP_224556578.1 | hypothetical protein | - |
| LOE13_RS08920 (LOE13_08915) | 1832871..1833323 | - | 453 | WP_224556581.1 | hypothetical protein | - |
| LOE13_RS08925 (LOE13_08920) | 1833399..1833569 | - | 171 | WP_224556583.1 | hypothetical protein | - |
| LOE13_RS08930 (LOE13_08925) | 1833669..1833857 | + | 189 | WP_224556585.1 | ribbon-helix-helix domain-containing protein | - |
| LOE13_RS08935 (LOE13_08930) | 1833969..1834223 | + | 255 | WP_224556587.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LOE13_RS08940 (LOE13_08935) | 1834220..1834549 | + | 330 | WP_224556600.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LOE13_RS08945 (LOE13_08940) | 1834610..1834873 | + | 264 | WP_224556602.1 | hypothetical protein | - |
| LOE13_RS08950 (LOE13_08945) | 1834975..1835265 | - | 291 | WP_224556604.1 | hypothetical protein | - |
| LOE13_RS08955 (LOE13_08950) | 1835328..1835852 | - | 525 | WP_224556606.1 | hypothetical protein | - |
| LOE13_RS08960 (LOE13_08955) | 1836072..1836995 | - | 924 | WP_229940510.1 | phage minor head protein | - |
| LOE13_RS08965 (LOE13_08960) | 1837117..1837281 | - | 165 | WP_229940508.1 | hypothetical protein | - |
| LOE13_RS08970 (LOE13_08965) | 1837278..1837694 | - | 417 | WP_229940505.1 | hypothetical protein | - |
| LOE13_RS08975 (LOE13_08970) | 1837691..1837996 | - | 306 | WP_224556620.1 | helix-turn-helix domain-containing protein | - |
| LOE13_RS08980 (LOE13_08975) | 1837993..1838247 | - | 255 | WP_224556623.1 | hypothetical protein | - |
| LOE13_RS08985 (LOE13_08980) | 1838244..1838402 | - | 159 | WP_224556625.1 | hypothetical protein | - |
| LOE13_RS08990 (LOE13_08985) | 1838399..1838587 | - | 189 | WP_224556628.1 | hypothetical protein | - |
| LOE13_RS08995 (LOE13_08990) | 1838587..1839477 | - | 891 | WP_229940766.1 | RNA ligase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1816277..1852649 | 36372 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9336.69 Da Isoelectric Point: 10.8025
>T224602 WP_224556587.1 NZ_CP086954:1833969-1834223 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP
Download Length: 255 bp
>T224602 NZ_CP120361:3225878-3226147 [Chelativorans sp. AA-79]
TTGACTTGGACGATTGAGGTCGATGACGCCGCACTGAGGCAACTTAAGAAAATTGGGCGGGTTGAAAGCAAACGCATTTA
CGGTTTTCTGCGTGAGCGGATAGCCACGCTCGACAATCCGCGAAAGCTGGGTGCGGCACTTCAAGGTTCAAGATTTGAGC
ACCTCTGGCGCTACCGCGTCGGCGATTACCGGATCATCTGCGACATCCAGGATCACAAGCTCGTCGTTCTCGTTCTGCAG
ATAGGCCACCGGCGAGAGATCTACCGCTGA
TTGACTTGGACGATTGAGGTCGATGACGCCGCACTGAGGCAACTTAAGAAAATTGGGCGGGTTGAAAGCAAACGCATTTA
CGGTTTTCTGCGTGAGCGGATAGCCACGCTCGACAATCCGCGAAAGCTGGGTGCGGCACTTCAAGGTTCAAGATTTGAGC
ACCTCTGGCGCTACCGCGTCGGCGATTACCGGATCATCTGCGACATCCAGGATCACAAGCTCGTCGTTCTCGTTCTGCAG
ATAGGCCACCGGCGAGAGATCTACCGCTGA
Antitoxin
Download Length: 110 a.a. Molecular weight: 12090.66 Da Isoelectric Point: 6.0876
>AT224602 WP_224556600.1 NZ_CP086954:1834220-1834549 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH
Download Length: 330 bp
>AT224602 NZ_CP120361:3225661-3225894 [Chelativorans sp. AA-79]
ATGAGCAAGCAAACAGCACTCCGGTTGCCAGACGAGACATATGAAAGATTGCGTGTCCTTTCCGAGCGAACAGGCCGGAC
GGCAGCTTATTATATGCGTCAGGCCATTGAACAGCACCTTGAGGATCTGGAGGATATCTATCTTGCAGAACAGGTGCTGG
AGCGCCTGAAGCGAGGTGAGAGCCGTACCTACACGCTTGCGGAAGTGGAACGCGAGCTTGACTTGGACGATTGA
ATGAGCAAGCAAACAGCACTCCGGTTGCCAGACGAGACATATGAAAGATTGCGTGTCCTTTCCGAGCGAACAGGCCGGAC
GGCAGCTTATTATATGCGTCAGGCCATTGAACAGCACCTTGAGGATCTGGAGGATATCTATCTTGCAGAACAGGTGCTGG
AGCGCCTGAAGCGAGGTGAGAGCCGTACCTACACGCTTGCGGAAGTGGAACGCGAGCTTGACTTGGACGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|