Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 70753..71427 Replicon plasmid P2
Accession NZ_CP086949
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-28

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE14_RS20925 Protein ID WP_224557924.1
Coordinates 71005..71427 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE14_RS20920 Protein ID WP_229939240.1
Coordinates 70753..71001 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE14_RS20900 (LOE14_20915) 66666..67310 + 645 WP_224557929.1 type IV secretion system protein -
LOE14_RS20905 (LOE14_20920) 67314..68045 + 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE14_RS20910 (LOE14_20925) 68048..69505 + 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE14_RS20915 (LOE14_20930) 69616..70605 + 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE14_RS20920 (LOE14_20935) 70753..71001 + 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE14_RS20925 (LOE14_20940) 71005..71427 + 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE14_RS20930 (LOE14_20945) 71424..74174 + 2751 WP_224557923.1 lactate dehydrogenase -
LOE14_RS20935 (LOE14_20950) 74171..75229 + 1059 WP_224557922.1 HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..157666 157666


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224599 WP_224557924.1 NZ_CP086949:71005-71427 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224599 NZ_CP120361:828649-829056 [Chelativorans sp. AA-79]
ATGAAGCCGCCCTTCATGCTGGACACCAATGTGGTGAGCGCCTTCATGCATGGCCGCAGCCGCGCCTTGGACAGGCGGAT
CTCAGCCTATGGGAAGGACGATCTTTGCGTTTCCGTCGTGAGCTATGGCGAGACCAGATACGGGCTCGCCCTGCGGCCTG
GGGCGAAACACCTTGCTGCCGCCGCGGAGCTGTTGTTCGGTCTCGTAAAAATATCGCCGTGGACGCCGGAGGCAGCATGC
CGCTACGGCGAGATGCGCGCCGAATTGCGCAGGCGGGGGCGCACGATGCAGCCGCTCGACATGCTCATCGCCGCGCACGC
GCTTGAAGCTGGCGCAACGCTGGTGACCAGCGACCGCGCGTTCCGCTTCGTGCCGGGGCTTGCCGTCGAGAACTGGCTCG
ACGACTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224599 WP_229939240.1 NZ_CP086949:70753-71001 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224599 NZ_CP120361:828392-828652 [Chelativorans sp. AA-79]
ATGCCCCGGACCGCAAAGCTTTTCTGGAATGGCCGCAGCCAAGCCGTGCGTCTGCCGGCGGAATTCCGCTTCGAGGGCGA
TGAGGTGGAAATTCGCCGCGATCCGGCCACGGGAGATGTGGTTCTCTCGCCCAAGCCGCAACGGACGGGATCGTGGGACA
GGTTTTTCAGGCTGCGTGACCAGATTCCTCCCGAGGAATTGGAAGGATTCATGGAGGATCGTGAGCAAGGACTCCATGAA
CGGGACGACCCGCTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References