Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2415122..2415702 Replicon chromosome
Accession NZ_CP086947
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-28

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE14_RS11690 Protein ID WP_224556587.1
Coordinates 2415122..2415376 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE14_RS11695 Protein ID WP_224556600.1
Coordinates 2415373..2415702 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE14_RS11655 (LOE14_11655) 2412145..2412468 + 324 WP_224556571.1 hypothetical protein -
LOE14_RS11660 (LOE14_11660) 2412546..2413061 - 516 WP_224556573.1 hypothetical protein -
LOE14_RS11665 (LOE14_11665) 2413039..2413866 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE14_RS11670 (LOE14_11670) 2413863..2414024 - 162 WP_224556578.1 hypothetical protein -
LOE14_RS11675 (LOE14_11675) 2414024..2414476 - 453 WP_224556581.1 hypothetical protein -
LOE14_RS11680 (LOE14_11680) 2414552..2414722 - 171 WP_224556583.1 hypothetical protein -
LOE14_RS11685 (LOE14_11685) 2414822..2415010 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE14_RS11690 (LOE14_11690) 2415122..2415376 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE14_RS11695 (LOE14_11695) 2415373..2415702 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE14_RS11700 (LOE14_11700) 2415763..2416026 + 264 WP_224556602.1 hypothetical protein -
LOE14_RS23660 2416013..2416135 - 123 WP_263481010.1 hypothetical protein -
LOE14_RS11705 (LOE14_11705) 2416128..2416418 - 291 WP_224556604.1 hypothetical protein -
LOE14_RS11710 (LOE14_11710) 2416481..2417005 - 525 WP_224556606.1 hypothetical protein -
LOE14_RS11715 (LOE14_11715) 2417260..2417697 - 438 WP_224556639.1 hypothetical protein -
LOE14_RS11720 (LOE14_11720) 2417785..2418216 - 432 WP_224556641.1 hypothetical protein -
LOE14_RS11725 (LOE14_11725) 2418220..2418888 - 669 WP_224556642.1 hypothetical protein -
LOE14_RS11730 (LOE14_11730) 2418885..2419082 - 198 WP_224556645.1 hypothetical protein -
LOE14_RS11735 (LOE14_11735) 2419172..2419807 + 636 WP_224556647.1 S24 family peptidase -
LOE14_RS11740 (LOE14_11740) 2420066..2420428 + 363 WP_224556648.1 type II toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2397430..2429610 32180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224596 WP_224556587.1 NZ_CP086947:2415122-2415376 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224596 NZ_CP120359:c4058665-4058096 [Pseudomonas sp. AA-38]
ATGTTCAAACCGCAATTGGTCACCTTGCAACGGGGTGCGCTGCGCCTGGAGCCGTTGGCCGATAACGACATCCCGGCATT
GGTGGCGCTGGCCGAGGCCAACCGTGAGGAGCTGCTGTACATGAATGGCACCCTGCGCCTGGACTGGTACCGCAGTGCGC
TGGCCGACCAGCGTGAACAACGGGCGCTGCCGTTCGTCATCCGCTTGGGCGATCGTCTAGTGGGTACCACGCGCTTCGCC
GATTTCCTCAATGCACTGCCGGCTTGCGAGATCGGCTGGACCTGGCTCGATCGTGAGCAGCATGGCAGTGGCCTGAATAC
CACCATCAAGTACCTGATGCTCAAGCATGCTTTCGACAACTGGGGCATGGTGCGTGTGCAGCTCAAGACCGCCGCCAGCA
ACCTGCGCTCGCAGCGCGCCATCGAAAAGCTCGGTGCCGTGCGCGAAGGCTTGCTGCGCAACCATCGGCGCCTGGCCGAC
GGCCGCCTCGACGATACGGTGCTGTACAGCATCACCGACCAGGAATGGCCGCAGGTGCGTCAGGCATTGGAAGCGAGCTT
CGGCGCCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224596 WP_224556600.1 NZ_CP086947:2415373-2415702 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224596 NZ_CP120359:c4058092-4057259 [Pseudomonas sp. AA-38]
ATGCAACCGGATGCAACGAGGGAGCACGTACGTTTCAGCACCAGCGCGGATGCGCAGGGGGTCGAGCTGTTGTCCGCGCG
TTTCATCGAGCACCGTTTCGCCCCTCACGTGCACGATGGGCATGTGATTGCGGTGCTCGAGGCGGGCGCCGAGCGTTATC
GCTATCGTGGTATCGAGCACCTGGCGGGGGCCGGTTGCATCGCTTTGCTCAACCCGGATGAGGTGCACACAGGCTCCAAG
GGGGCCGAGCAGGGATGGCAGTATCGGGTGTTCTATCCGCAGCCTGGCACCTTCGACACCCTGCTCGAGGAGTTGGAGCT
GCGGCCGAGCACGCCGATGTTTCAGGACAGCGTGCACCATGATCCGCTGCTGGCTACACGGCTGAGCGTTCTGCACCGCC
TGCTGGAGACTCCGCGCAGTGATGCCTTGCAACGGCAGACCCTGTGGCGTGAGGTGATGCTCGAACTGTTGCAGCGCTAT
GCGCGCCTGCCGGTGCCGCGCGCAGCCGGGCGCGAGCCACGGGTAGTGGCCATGGCCAAGGAGCTTCTGGCCAGTCGGTT
GTACGAGCCGCCGTCACTGGAGATGCTGGCGGAGAGCGTCAATCTCTCGCCTTTTCATTTCGCCCGGGTCTTTCGTCGCG
CCACCGGCTTGCCACCCCATGCCTGGCTCAAGCAGCGACGCCTGGAGCAGGCTAGGGCCCTGTTGCGACAGGGCAGTGCA
CCGCTGTCGGTAGCGATGCAACTGGGCTTTGCCGACCAGAGTCACCTGTCGCGCCAGTTCAAGCAGGCCTACGGTATTGC
CCCCGGCGAATATCGACGGGCTTGCCAGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References