Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 25895..26507 Replicon plasmid P6
Accession NZ_CP086944
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-29

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE15_RS21860 Protein ID WP_028288627.1
Coordinates 26112..26507 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE15_RS21855 Protein ID WP_009503866.1
Coordinates 25895..26122 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE15_RS21840 (LOE15_21795) 22152..23363 - 1212 WP_050525470.1 plasmid replication protein RepC -
LOE15_RS21845 (LOE15_21800) 23577..24509 - 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE15_RS21850 (LOE15_21805) 24493..25686 - 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE15_RS21855 (LOE15_21810) 25895..26122 + 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE15_RS21860 (LOE15_21815) 26112..26507 + 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE15_RS21865 (LOE15_21820) 26586..27077 - 492 Protein_28 recombinase family protein -
LOE15_RS21870 (LOE15_21825) 27179..28318 - 1140 WP_229940649.1 tyrosine-type recombinase/integrase -
LOE15_RS21875 (LOE15_21830) 28445..29329 + 885 WP_037239259.1 DUF1403 family protein -
LOE15_RS21880 (LOE15_21835) 29377..29988 + 612 WP_197919471.1 SMC-Scp complex subunit ScpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110565 110565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224594 WP_028288627.1 NZ_CP086944:26112-26507 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224594 NZ_CP120359:c2463746-2463402 [Pseudomonas sp. AA-38]
ATGAAAGCATTGTTCGTTGAACTGTCACCCTTTGAGCGCAACCGAAAAGCCTACCTGGATGACGGCGAATACTCGCTATT
CCAACAGATGCTCTTGGCCAACCCGGAGGCAGGCGCAGTCATCGCCAACAGCGGTGGTCTGAGGAAGGTCCGCTTCGGAT
CGGCCAGGCGCAACAAAGGGAAGCGCGGTGGCGTTCGGGTGATTTACTACTACTGGCACAGCTGTCTGCAGTTCTGGCTC
TTCACCCTGTATGACAAAGACGAACTCGATGACCTGAGCAGTGACCAGCGCAGACAGTTGAAAGCGCTCCTTGAGCGCGA
AGTGAAGACGAGGCAAGCACCATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224594 WP_009503866.1 NZ_CP086944:25895-26122 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224594 NZ_CP120359:c2463405-2463097 [Pseudomonas sp. AA-38]
ATGACCAAACGCGATATTTTTTCCGAGCTGATCGAAGGCTTCGATGACCTGGCCGCAGCACGTGAAGGCAAGCGTACGCT
GCGTACCCACAAGGTCGAATACACGCCAATCGAGCCCGCGACAGGTGCGGAAATCGTCGCACTGCGCGAAAAGCTGAAGA
TGTCTCAGGGTGTATTCGCCCAGGCCATTCACGCCAAGCCTGCGACCCTCAAGAACTGGGAGCAGAACCGCTCAAAGCCC
AACGATCAGGCCACTGTCTTGATCCGTATCCTGAGCAAGCATCCAGAACTCATACGCGAGCTGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References