Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1956750..1957330 Replicon chromosome
Accession NZ_CP086938
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-29

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE15_RS09575 Protein ID WP_224556587.1
Coordinates 1956750..1957004 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE15_RS09580 Protein ID WP_224556600.1
Coordinates 1957001..1957330 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE15_RS09540 (LOE15_09520) 1953773..1954096 + 324 WP_224556571.1 hypothetical protein -
LOE15_RS09545 (LOE15_09525) 1954174..1954689 - 516 WP_224556573.1 hypothetical protein -
LOE15_RS09550 (LOE15_09530) 1954667..1955494 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE15_RS09555 (LOE15_09535) 1955491..1955652 - 162 WP_224556578.1 hypothetical protein -
LOE15_RS09560 (LOE15_09540) 1955652..1956104 - 453 WP_224556581.1 hypothetical protein -
LOE15_RS09565 (LOE15_09545) 1956180..1956350 - 171 WP_224556583.1 hypothetical protein -
LOE15_RS09570 (LOE15_09550) 1956450..1956638 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE15_RS09575 (LOE15_09555) 1956750..1957004 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE15_RS09580 (LOE15_09560) 1957001..1957330 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE15_RS09585 (LOE15_09565) 1957391..1957654 + 264 WP_224556602.1 hypothetical protein -
LOE15_RS23560 1957641..1957763 - 123 WP_263481010.1 hypothetical protein -
LOE15_RS09590 (LOE15_09570) 1957756..1958046 - 291 WP_224556604.1 hypothetical protein -
LOE15_RS09595 (LOE15_09575) 1958109..1958633 - 525 WP_224556606.1 hypothetical protein -
LOE15_RS09600 (LOE15_09580) 1958853..1959776 - 924 WP_229940510.1 phage minor head protein -
LOE15_RS09605 (LOE15_09585) 1959898..1960062 - 165 WP_229940508.1 hypothetical protein -
LOE15_RS09610 (LOE15_09590) 1960059..1960475 - 417 WP_229940505.1 hypothetical protein -
LOE15_RS09615 (LOE15_09595) 1960472..1960777 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE15_RS09620 (LOE15_09600) 1960774..1961028 - 255 WP_224556623.1 hypothetical protein -
LOE15_RS09625 (LOE15_09605) 1961025..1961183 - 159 WP_224556625.1 hypothetical protein -
LOE15_RS09630 (LOE15_09610) 1961180..1961368 - 189 WP_224556628.1 hypothetical protein -
LOE15_RS09635 (LOE15_09615) 1961368..1962255 - 888 WP_224556631.1 RNA ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1939058..1976571 37513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224590 WP_224556587.1 NZ_CP086938:1956750-1957004 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224590 NZ_CP120353:3478997-3479257 [Parabacteroides distasonis]
ATGGGTTCTAAAGAAAAGTTGATCGAGCGTTTTTGTAAACTACCTAAAGATTTCACCTACGAGGAAACTTTAAAATTGCT
TTCTTCTTATGGCTATAACGAGCATAATAAAGGTGCAACGTCAGGTTCTCGCGTGAGATTTAAAAATGAACAGACGGGAC
AATATATTGATATTCATAAACCGCATCCGGGTAGTATTATGAAGGAGTGGATGATGAAAGCGATATATCAGCATTTAAAA
AGTAATGGTTTAATTAAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224590 WP_224556600.1 NZ_CP086938:1957001-1957330 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224590 NZ_CP120353:3479269-3479610 [Parabacteroides distasonis]
ATGGACTATTTGGAATACAAAGGTTATAAAGGTTCTGTTGAGTACAGTAAGGCTGATAACTGTCTTTGCGGAAAGGTACT
TGGTATGAGTAAAGATTTAATTCTTTATGAAGGTAATACTATCGATGAACTTCGTGCGGATTTTGAAGCCGGAGTAGAAA
GCTATCTTGCCGGCTGTTTGGCTGATGGCGTGGAACCTCGTAAACCTTATAGTGGCACGTTAAATATCCGTATTTCACCA
GAAATACATAGCCGAATCGCAGCATTGGCGCAAGAGGCGGGAACTACGATTAACGGGTATATAAAACAGGCTTTGGAGAA
TCAGTTGAAGCTTGCCCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References