Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 84566..85031 Replicon chromosome
Accession NZ_CP086938
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-29

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE15_RS00450 Protein ID WP_224557762.1
Coordinates 84566..84829 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE15_RS00455 Protein ID WP_224557764.1
Coordinates 84816..85031 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE15_RS00425 (LOE15_00425) 80283..81833 - 1551 WP_224557015.1 restriction endonuclease subunit S -
LOE15_RS00430 (LOE15_00430) 81830..82126 - 297 WP_224557153.1 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -
LOE15_RS00435 (LOE15_00435) 82020..82508 - 489 WP_229938596.1 DEAD/DEAH box helicase family protein -
LOE15_RS00440 (LOE15_00440) 82734..83842 - 1109 Protein_84 IS110 family transposase -
LOE15_RS00445 (LOE15_00445) 83935..84378 - 444 WP_224557760.1 hypothetical protein -
LOE15_RS00450 (LOE15_00450) 84566..84829 + 264 WP_224557762.1 BrnT family toxin Toxin
LOE15_RS00455 (LOE15_00455) 84816..85031 + 216 WP_224557764.1 CopG family antitoxin Antitoxin
LOE15_RS00460 (LOE15_00460) 85384..85608 - 225 WP_224557765.1 hypothetical protein -
LOE15_RS00465 (LOE15_00465) 85776..86156 - 381 WP_224557766.1 helix-turn-helix domain-containing protein -
LOE15_RS00470 (LOE15_00470) 86337..87308 - 972 WP_224557767.1 hypothetical protein -
LOE15_RS00475 (LOE15_00475) 87301..88485 - 1185 WP_224557768.1 site-specific integrase -
LOE15_RS00485 (LOE15_00485) 88863..89561 - 699 WP_037931342.1 SURF1 family protein -
LOE15_RS00490 (LOE15_00490) 89558..89923 - 366 WP_028957811.1 cytochrome o ubiquinol oxidase subunit IV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10254.52 Da        Isoelectric Point: 5.6550

>T224589 WP_224557762.1 NZ_CP086938:84566-84829 [Pseudosulfitobacter pseudonitzschiae]
MKFEYDPDKSAGNKAKHGIDFDEAQALWEDPWLLEAPARTDDEPRFFAIGMIKERHWSAVCTYRGDIIRIISVRRARKQE
IEHYEST

Download         Length: 264 bp

>T224589 NZ_CP120352:1157348-1157623 [Ligilactobacillus murinus]
TTGAAAGAATACCATGTTGAATACTCAAAAAGAGCACAAAAACAAATCAAGAAATTAGATAGACAAATTCAACGGTTGCT
ATTTGCCTGGATAGATAAAAATCTTGAAGGCGTATCTGATCCACGCATACATGGTAAAGGTTTGACTGGAAACCATGCTC
GTGAATGGAGATATAGAATTGGCGACTACCGCCTTATATGTGATATTCAAGATGACATAATGATTATCTTGGCTTTGGAA
TTTGGTCACAGAAGATCCGTGTATAATAAAAAATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8265.40 Da        Isoelectric Point: 10.6538

>AT224589 WP_224557764.1 NZ_CP086938:84816-85031 [Pseudosulfitobacter pseudonitzschiae]
MKAREFDQKFDTGENVSDLVDWSKARRTNTQTKRVNVDFPSWVVSGLDQKAKQLGVTRQSLIKLWIAERLQ

Download         Length: 216 bp

>AT224589 NZ_CP120352:1157130-1157351 [Ligilactobacillus murinus]
ATGGCTACTATTAGTATCAGGCTAAACCAACAAGAAGAAGAACTTTTTAAAGGATATGCAGAACTTACTGGAGAAAACTT
GTCTACTCTCTTCAAAGAAGCTCTTAAAAAAAGCATTGATGATGAATACGATCTTCAGGTATACAAAGAAGCATATAAAG
AGTATCAGCAAGATCCAGTAACTATCTCACATGCTGACTTTAAAAAGGAGTTAGGTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References