Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1339503..1340083 Replicon chromosome
Accession NZ_CP086930
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-30

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE16_RS07060 Protein ID WP_224556587.1
Coordinates 1339829..1340083 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE16_RS07055 Protein ID WP_224556600.1
Coordinates 1339503..1339832 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE16_RS07000 (LOE16_07000) 1334578..1335465 + 888 WP_224556631.1 RNA ligase family protein -
LOE16_RS07005 (LOE16_07005) 1335465..1335653 + 189 WP_224556628.1 hypothetical protein -
LOE16_RS07010 (LOE16_07010) 1335650..1335808 + 159 WP_224556625.1 hypothetical protein -
LOE16_RS07015 (LOE16_07015) 1335805..1336059 + 255 WP_224556623.1 hypothetical protein -
LOE16_RS07020 (LOE16_07020) 1336056..1336361 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE16_RS07025 (LOE16_07025) 1336358..1336774 + 417 WP_229940505.1 hypothetical protein -
LOE16_RS07030 (LOE16_07030) 1336771..1336935 + 165 WP_229940508.1 hypothetical protein -
LOE16_RS07035 (LOE16_07035) 1337057..1337980 + 924 WP_229940510.1 phage minor head protein -
LOE16_RS07040 (LOE16_07040) 1338200..1338724 + 525 WP_224556606.1 hypothetical protein -
LOE16_RS07045 (LOE16_07045) 1338787..1339077 + 291 WP_224556604.1 hypothetical protein -
LOE16_RS22675 1339070..1339192 + 123 WP_263481010.1 hypothetical protein -
LOE16_RS07050 (LOE16_07050) 1339179..1339406 - 228 WP_229940862.1 hypothetical protein -
LOE16_RS07055 (LOE16_07055) 1339503..1339832 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE16_RS07060 (LOE16_07060) 1339829..1340083 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE16_RS07065 (LOE16_07065) 1340195..1340383 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE16_RS07070 (LOE16_07070) 1340483..1340653 + 171 WP_224556583.1 hypothetical protein -
LOE16_RS07075 (LOE16_07075) 1340729..1341181 + 453 WP_224556581.1 hypothetical protein -
LOE16_RS07080 (LOE16_07080) 1341181..1341342 + 162 WP_224556578.1 hypothetical protein -
LOE16_RS07085 (LOE16_07085) 1341339..1342166 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE16_RS07090 (LOE16_07090) 1342144..1342659 + 516 WP_224556573.1 hypothetical protein -
LOE16_RS07095 (LOE16_07095) 1342737..1343060 - 324 WP_224556571.1 hypothetical protein -
LOE16_RS07100 (LOE16_07100) 1343275..1343817 - 543 WP_229940519.1 hypothetical protein -
LOE16_RS07105 (LOE16_07105) 1344380..1344628 - 249 WP_229940863.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1321702..1358323 36621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224583 WP_224556587.1 NZ_CP086930:c1340083-1339829 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224583 NZ_CP120349:c4666509-4666198 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224583 WP_224556600.1 NZ_CP086930:c1339832-1339503 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224583 NZ_CP120349:c4666197-4665907 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References