Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 82357..83031 Replicon plasmid P4
Accession NZ_CP086923
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-32

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE17_RS21530 Protein ID WP_224557924.1
Coordinates 82357..82779 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE17_RS21535 Protein ID WP_229939240.1
Coordinates 82783..83031 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE17_RS21520 (LOE17_21490) 78555..79613 - 1059 WP_224557922.1 HEPN domain-containing protein -
LOE17_RS21525 (LOE17_21495) 79610..82360 - 2751 WP_224557923.1 lactate dehydrogenase -
LOE17_RS21530 (LOE17_21500) 82357..82779 - 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE17_RS21535 (LOE17_21505) 82783..83031 - 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE17_RS21540 (LOE17_21510) 83179..84168 - 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE17_RS21545 (LOE17_21515) 84279..85736 - 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE17_RS21550 (LOE17_21520) 85739..86470 - 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE17_RS21555 (LOE17_21525) 86474..87118 - 645 WP_224557929.1 type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..97226 97226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224579 WP_224557924.1 NZ_CP086923:c82779-82357 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224579 NZ_CP120349:3522074-3522292 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224579 WP_229939240.1 NZ_CP086923:c83031-82783 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224579 NZ_CP120349:3521672-3522046 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References