Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2022328..2022908 Replicon chromosome
Accession NZ_CP086919
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-32

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE17_RS10345 Protein ID WP_224556587.1
Coordinates 2022654..2022908 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE17_RS10340 Protein ID WP_224556600.1
Coordinates 2022328..2022657 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE17_RS10285 (LOE17_10275) 2017403..2018290 + 888 WP_224556631.1 RNA ligase family protein -
LOE17_RS10290 (LOE17_10280) 2018290..2018478 + 189 WP_224556628.1 hypothetical protein -
LOE17_RS10295 (LOE17_10285) 2018475..2018633 + 159 WP_224556625.1 hypothetical protein -
LOE17_RS10300 (LOE17_10290) 2018630..2018884 + 255 WP_224556623.1 hypothetical protein -
LOE17_RS10305 (LOE17_10295) 2018881..2019186 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE17_RS10310 (LOE17_10300) 2019183..2019599 + 417 WP_229940505.1 hypothetical protein -
LOE17_RS10315 (LOE17_10305) 2019596..2019760 + 165 WP_229940508.1 hypothetical protein -
LOE17_RS10320 (LOE17_10310) 2019882..2020805 + 924 WP_229940510.1 phage minor head protein -
LOE17_RS10325 (LOE17_10315) 2021025..2021549 + 525 WP_224556606.1 hypothetical protein -
LOE17_RS10330 (LOE17_10320) 2021612..2021902 + 291 WP_224556604.1 hypothetical protein -
LOE17_RS25040 2021895..2022017 + 123 WP_263481010.1 hypothetical protein -
LOE17_RS10335 (LOE17_10325) 2022004..2022267 - 264 WP_224556602.1 hypothetical protein -
LOE17_RS10340 (LOE17_10330) 2022328..2022657 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE17_RS10345 (LOE17_10335) 2022654..2022908 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE17_RS10350 (LOE17_10340) 2023020..2023208 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE17_RS10355 (LOE17_10345) 2023308..2023478 + 171 WP_224556583.1 hypothetical protein -
LOE17_RS10360 (LOE17_10350) 2023554..2024006 + 453 WP_224556581.1 hypothetical protein -
LOE17_RS10365 (LOE17_10355) 2024006..2024167 + 162 WP_224556578.1 hypothetical protein -
LOE17_RS10370 (LOE17_10360) 2024164..2024991 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE17_RS10375 (LOE17_10365) 2024969..2025484 + 516 WP_224556573.1 hypothetical protein -
LOE17_RS10380 (LOE17_10370) 2025562..2025885 - 324 WP_224556571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2004527..2041148 36621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224576 WP_224556587.1 NZ_CP086919:c2022908-2022654 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224576 NZ_CP120349:854966-855379 [Salmonella enterica subsp. enterica serovar Muenchen]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTAATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGTTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224576 WP_224556600.1 NZ_CP086919:c2022657-2022328 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224576 NZ_CP120349:854719-854985 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References