Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2858240..2858820 Replicon chromosome
Accession NZ_CP086909
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-34

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE18_RS14115 Protein ID WP_224556587.1
Coordinates 2858240..2858494 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE18_RS14120 Protein ID WP_224556600.1
Coordinates 2858491..2858820 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE18_RS14070 2853695..2853943 + 249 WP_229940863.1 hypothetical protein -
LOE18_RS14075 2854506..2855048 + 543 WP_229940519.1 hypothetical protein -
LOE18_RS14080 (LOE18_14040) 2855263..2855586 + 324 WP_224556571.1 hypothetical protein -
LOE18_RS14085 (LOE18_14045) 2855664..2856179 - 516 WP_224556573.1 hypothetical protein -
LOE18_RS14090 (LOE18_14050) 2856157..2856984 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE18_RS14095 (LOE18_14055) 2856981..2857142 - 162 WP_224556578.1 hypothetical protein -
LOE18_RS14100 (LOE18_14060) 2857142..2857594 - 453 WP_224556581.1 hypothetical protein -
LOE18_RS14105 (LOE18_14065) 2857670..2857840 - 171 WP_224556583.1 hypothetical protein -
LOE18_RS14110 (LOE18_14070) 2857940..2858128 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE18_RS14115 (LOE18_14075) 2858240..2858494 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE18_RS14120 (LOE18_14080) 2858491..2858820 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE18_RS14125 (LOE18_14085) 2858881..2859144 + 264 WP_224556602.1 hypothetical protein -
LOE18_RS24835 2859131..2859253 - 123 WP_263481010.1 hypothetical protein -
LOE18_RS14130 (LOE18_14090) 2859246..2859536 - 291 WP_224556604.1 hypothetical protein -
LOE18_RS14135 (LOE18_14095) 2859599..2860123 - 525 WP_224556606.1 hypothetical protein -
LOE18_RS14140 (LOE18_14100) 2860343..2861266 - 924 WP_229940510.1 phage minor head protein -
LOE18_RS14145 (LOE18_14105) 2861388..2861552 - 165 WP_229940508.1 hypothetical protein -
LOE18_RS14150 (LOE18_14110) 2861549..2861965 - 417 WP_229940505.1 hypothetical protein -
LOE18_RS14155 (LOE18_14115) 2861962..2862267 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE18_RS14160 (LOE18_14120) 2862264..2862518 - 255 WP_224556623.1 hypothetical protein -
LOE18_RS14165 (LOE18_14125) 2862515..2862673 - 159 WP_224556625.1 hypothetical protein -
LOE18_RS14170 (LOE18_14130) 2862670..2862858 - 189 WP_224556628.1 hypothetical protein -
LOE18_RS14175 (LOE18_14135) 2862858..2863745 - 888 WP_224556631.1 RNA ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2840548..2878061 37513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224569 WP_224556587.1 NZ_CP086909:2858240-2858494 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224569 NZ_CP120347:c4666510-4666199 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224569 WP_224556600.1 NZ_CP086909:2858491-2858820 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224569 NZ_CP120347:c4666198-4665908 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References