Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 178095..178707 Replicon plasmid P4
Accession NZ_CP086905
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-35

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE19_RS23265 Protein ID WP_028288627.1
Coordinates 178095..178490 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE19_RS23270 Protein ID WP_009503866.1
Coordinates 178480..178707 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE19_RS23245 (LOE19_23245) 174675..175271 - 597 WP_109535033.1 SMC-Scp complex subunit ScpB -
LOE19_RS23250 (LOE19_23250) 175275..176159 - 885 WP_229939227.1 DUF1403 family protein -
LOE19_RS23255 (LOE19_23255) 176371..177423 + 1053 WP_229997160.1 tyrosine-type recombinase/integrase -
LOE19_RS23260 (LOE19_23260) 177525..178016 + 492 Protein_184 recombinase family protein -
LOE19_RS23265 (LOE19_23265) 178095..178490 - 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE19_RS23270 (LOE19_23270) 178480..178707 - 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE19_RS23275 (LOE19_23275) 178916..180109 + 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE19_RS23280 (LOE19_23280) 180093..181025 + 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE19_RS23285 (LOE19_23285) 181239..182450 + 1212 WP_050525470.1 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..197667 197667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224565 WP_028288627.1 NZ_CP086905:c178490-178095 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224565 NZ_CP120347:3522075-3522293 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224565 WP_009503866.1 NZ_CP086905:c178707-178480 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224565 NZ_CP120347:3521673-3522047 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References