Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 378372..378952 Replicon chromosome
Accession NZ_CP086901
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-35

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE19_RS01970 Protein ID WP_224556587.1
Coordinates 378698..378952 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE19_RS01965 Protein ID WP_224556600.1
Coordinates 378372..378701 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE19_RS01910 (LOE19_01920) 373444..374334 + 891 WP_229940766.1 RNA ligase family protein -
LOE19_RS01915 (LOE19_01925) 374334..374522 + 189 WP_224556628.1 hypothetical protein -
LOE19_RS01920 (LOE19_01930) 374519..374677 + 159 WP_224556625.1 hypothetical protein -
LOE19_RS01925 (LOE19_01935) 374674..374928 + 255 WP_224556623.1 hypothetical protein -
LOE19_RS01930 (LOE19_01940) 374925..375230 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE19_RS01935 (LOE19_01945) 375227..375643 + 417 WP_229940505.1 hypothetical protein -
LOE19_RS01940 (LOE19_01950) 375640..375804 + 165 WP_229940508.1 hypothetical protein -
LOE19_RS01945 (LOE19_01955) 375926..376849 + 924 WP_229940510.1 phage minor head protein -
LOE19_RS01950 (LOE19_01960) 377069..377593 + 525 WP_224556606.1 hypothetical protein -
LOE19_RS01955 (LOE19_01965) 377656..377946 + 291 WP_224556604.1 hypothetical protein -
LOE19_RS01960 (LOE19_01970) 378048..378311 - 264 WP_224556602.1 hypothetical protein -
LOE19_RS01965 (LOE19_01975) 378372..378701 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE19_RS01970 (LOE19_01980) 378698..378952 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE19_RS01975 (LOE19_01985) 379064..379252 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE19_RS01980 (LOE19_01990) 379352..379522 + 171 WP_224556583.1 hypothetical protein -
LOE19_RS01985 (LOE19_01995) 379598..380050 + 453 WP_224556581.1 hypothetical protein -
LOE19_RS01990 (LOE19_02000) 380050..380211 + 162 WP_224556578.1 hypothetical protein -
LOE19_RS01995 (LOE19_02005) 380208..381035 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE19_RS02000 (LOE19_02010) 381013..381528 + 516 WP_224556573.1 hypothetical protein -
LOE19_RS02005 (LOE19_02015) 381606..381983 - 378 WP_229940765.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 361788..397192 35404


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224561 WP_224556587.1 NZ_CP086901:c378952-378698 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224561 NZ_CP120347:311879-312247 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224561 WP_224556600.1 NZ_CP086901:c378701-378372 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224561 NZ_CP120347:311661-311882 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References