Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 1833961..1834541 | Replicon | chromosome |
| Accession | NZ_CP086894 | ||
| Organism | Pseudosulfitobacter pseudonitzschiae strain SC1-37 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LOE20_RS08930 | Protein ID | WP_224556587.1 |
| Coordinates | 1833961..1834215 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LOE20_RS08935 | Protein ID | WP_224556600.1 |
| Coordinates | 1834212..1834541 (+) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOE20_RS08895 (LOE20_08900) | 1830984..1831307 | + | 324 | WP_224556571.1 | hypothetical protein | - |
| LOE20_RS08900 (LOE20_08905) | 1831385..1831900 | - | 516 | WP_224556573.1 | hypothetical protein | - |
| LOE20_RS08905 (LOE20_08910) | 1831878..1832705 | - | 828 | WP_224556575.1 | ParB N-terminal domain-containing protein | - |
| LOE20_RS08910 (LOE20_08915) | 1832702..1832863 | - | 162 | WP_224556578.1 | hypothetical protein | - |
| LOE20_RS08915 (LOE20_08920) | 1832863..1833315 | - | 453 | WP_224556581.1 | hypothetical protein | - |
| LOE20_RS08920 (LOE20_08925) | 1833391..1833561 | - | 171 | WP_224556583.1 | hypothetical protein | - |
| LOE20_RS08925 (LOE20_08930) | 1833661..1833849 | + | 189 | WP_224556585.1 | ribbon-helix-helix domain-containing protein | - |
| LOE20_RS08930 (LOE20_08935) | 1833961..1834215 | + | 255 | WP_224556587.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LOE20_RS08935 (LOE20_08940) | 1834212..1834541 | + | 330 | WP_224556600.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LOE20_RS08940 (LOE20_08945) | 1834602..1834865 | + | 264 | WP_224556602.1 | hypothetical protein | - |
| LOE20_RS24335 | 1834852..1834974 | - | 123 | WP_263481010.1 | hypothetical protein | - |
| LOE20_RS08945 (LOE20_08950) | 1834967..1835257 | - | 291 | WP_224556604.1 | hypothetical protein | - |
| LOE20_RS08950 (LOE20_08955) | 1835320..1835844 | - | 525 | WP_224556606.1 | hypothetical protein | - |
| LOE20_RS08955 (LOE20_08960) | 1836064..1836987 | - | 924 | WP_229940510.1 | phage minor head protein | - |
| LOE20_RS08960 (LOE20_08965) | 1837109..1837273 | - | 165 | WP_229940508.1 | hypothetical protein | - |
| LOE20_RS08965 (LOE20_08970) | 1837270..1837686 | - | 417 | WP_229940505.1 | hypothetical protein | - |
| LOE20_RS08970 (LOE20_08975) | 1837683..1837988 | - | 306 | WP_224556620.1 | helix-turn-helix domain-containing protein | - |
| LOE20_RS08975 (LOE20_08980) | 1837985..1838239 | - | 255 | WP_224556623.1 | hypothetical protein | - |
| LOE20_RS08980 (LOE20_08985) | 1838236..1838394 | - | 159 | WP_224556625.1 | hypothetical protein | - |
| LOE20_RS08985 (LOE20_08990) | 1838391..1838579 | - | 189 | WP_224556628.1 | hypothetical protein | - |
| LOE20_RS08990 (LOE20_08995) | 1838579..1839466 | - | 888 | WP_224556631.1 | RNA ligase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1816269..1853782 | 37513 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9336.69 Da Isoelectric Point: 10.8025
>T224554 WP_224556587.1 NZ_CP086894:1833961-1834215 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP
Download Length: 255 bp
>T224554 NZ_CP120345:c4216810-4216526 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
Antitoxin
Download Length: 110 a.a. Molecular weight: 12090.66 Da Isoelectric Point: 6.0876
>AT224554 WP_224556600.1 NZ_CP086894:1834212-1834541 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH
Download Length: 330 bp
>AT224554 NZ_CP120345:c4217042-4216800 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|