Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 25892..26504 Replicon plasmid P5
Accession NZ_CP086891
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-67

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE21_RS21860 Protein ID WP_028288627.1
Coordinates 26109..26504 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE21_RS21855 Protein ID WP_009503866.1
Coordinates 25892..26119 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE21_RS21840 (LOE21_21840) 22149..23360 - 1212 WP_050525470.1 plasmid replication protein RepC -
LOE21_RS21845 (LOE21_21845) 23574..24506 - 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE21_RS21850 (LOE21_21850) 24490..25683 - 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE21_RS21855 (LOE21_21855) 25892..26119 + 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE21_RS21860 (LOE21_21860) 26109..26504 + 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE21_RS21865 (LOE21_21865) 26583..27074 - 492 Protein_28 recombinase family protein -
LOE21_RS21870 (LOE21_21870) 27176..28327 - 1152 WP_224557873.1 tyrosine-type recombinase/integrase -
LOE21_RS21875 (LOE21_21875) 28442..29326 + 885 WP_037239259.1 DUF1403 family protein -
LOE21_RS21880 (LOE21_21880) 29374..29985 + 612 WP_197919471.1 SMC-Scp complex subunit ScpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110560 110560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224553 WP_028288627.1 NZ_CP086891:26109-26504 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224553 NZ_CP120345:c4165963-4165625 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAAAATCCTTTCTGCAAATCAGCGGGTGGCGAAGCCATGCCCGCCGCCTGTACTTGTCTGGCAAACGCTACTGACACG
CCTGCTGGAGCAACACTATGGCCTGTCGCTGAACGATACGCCGTTCAGTGATGAAACGGTTATTCAGGAGCATATCAACG
CCGGTATCACGCTGGCGGATGCAGTTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTTAAC
TGTCAGGAACAGTCGCCTTACCTTCGGGCGGTTGATATTTTACGGGCGCGACAGGCTACTGGTCTGTTGCGGCAAAACCA
GCTTCCTTCGACACGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224553 WP_009503866.1 NZ_CP086891:25892-26119 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224553 NZ_CP120345:c4166317-4165988 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGATAAAGAAACCGACACAGTACAGTGGGGACTCAACCGACCTGGTTCTCCTCAATTTAGCGCACGCCTGGTACAAGA
AGGCAAACGCCTACATTATTTAGCTGACCGCGCCGGGATAACAGGCGCTTTCAATGAAGAAGAGTGTCACCAACTGAATG
CCGCATTTCCGCACTTCGTAAAACAAATGGAGCTGATGCTGCTCTCTGGTGAGCTTAACCCCCGCCATGCATATCGCGTA
ACGCTGTACCACAACGAACTGACCTGTGAAGCAGATACGCTCGGTAGCTGTGGCTACGTTTATATAGCGATTTATCCCAC
TCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References