Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 79859..80533 Replicon plasmid P3
Accession NZ_CP086889
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-67

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE21_RS20765 Protein ID WP_224557924.1
Coordinates 79859..80281 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE21_RS20770 Protein ID WP_229939240.1
Coordinates 80285..80533 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE21_RS20755 (LOE21_20755) 76057..77115 - 1059 WP_224557922.1 HEPN domain-containing protein -
LOE21_RS20760 (LOE21_20760) 77112..79862 - 2751 WP_224557923.1 lactate dehydrogenase -
LOE21_RS20765 (LOE21_20765) 79859..80281 - 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE21_RS20770 (LOE21_20770) 80285..80533 - 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE21_RS20775 (LOE21_20775) 80681..81670 - 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE21_RS20780 (LOE21_20780) 81781..83238 - 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE21_RS20785 (LOE21_20785) 83241..83972 - 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE21_RS20790 (LOE21_20790) 83976..84620 - 645 WP_224557929.1 type IV secretion system protein -
LOE21_RS20795 (LOE21_20795) 84623..85174 - 552 WP_229940781.1 type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..85251 85251


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224552 WP_224557924.1 NZ_CP086889:c80281-79859 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224552 NZ_CP120345:3723631-3723906 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAATGCCTCCGGCGTTAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224552 WP_229939240.1 NZ_CP086889:c80533-80285 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224552 NZ_CP120345:c3723896-3723474 [Salmonella enterica subsp. enterica serovar Muenchen]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTAACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References