Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 48922..49483 | Replicon | plasmid P1 |
| Accession | NZ_CP086887 | ||
| Organism | Pseudosulfitobacter pseudonitzschiae strain SC1-67 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | LOE21_RS19405 | Protein ID | WP_224557555.1 |
| Coordinates | 48922..49197 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | LOE21_RS19410 | Protein ID | WP_224557554.1 |
| Coordinates | 49190..49483 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOE21_RS19390 (LOE21_19390) | 44711..46027 | - | 1317 | WP_224557560.1 | lactate racemase domain-containing protein | - |
| LOE21_RS19395 (LOE21_19395) | 46044..47591 | - | 1548 | WP_224557559.1 | altronate dehydratase family protein | - |
| LOE21_RS19400 (LOE21_19400) | 47716..48453 | + | 738 | WP_229940771.1 | GntR family transcriptional regulator | - |
| LOE21_RS19405 (LOE21_19405) | 48922..49197 | - | 276 | WP_224557555.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LOE21_RS19410 (LOE21_19410) | 49190..49483 | - | 294 | WP_224557554.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LOE21_RS19415 (LOE21_19415) | 49554..50459 | - | 906 | WP_224557552.1 | dihydrodipicolinate synthase family protein | - |
| LOE21_RS19420 (LOE21_19420) | 50470..52209 | - | 1740 | WP_224557550.1 | L-arabinonate dehydratase | - |
| LOE21_RS19425 (LOE21_19425) | 52471..54006 | + | 1536 | WP_224557548.1 | aldehyde dehydrogenase (NADP(+)) | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..82312 | 82312 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10108.67 Da Isoelectric Point: 4.4912
>T224550 WP_224557555.1 NZ_CP086887:c49197-48922 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP
Download Length: 276 bp
>T224550 NZ_CP120345:2101786-2101889 [Salmonella enterica subsp. enterica serovar Muenchen]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 98 a.a. Molecular weight: 10166.59 Da Isoelectric Point: 7.2024
>AT224550 WP_224557554.1 NZ_CP086887:c49483-49190 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA
Download Length: 294 bp
>AT224550 NZ_CP120345:c2101891-2101746 [Salmonella enterica subsp. enterica serovar Muenchen]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|