Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1830118..1830698 Replicon chromosome
Accession NZ_CP086886
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-67

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE21_RS08900 Protein ID WP_224556587.1
Coordinates 1830118..1830372 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE21_RS08905 Protein ID WP_224556600.1
Coordinates 1830369..1830698 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE21_RS08865 (LOE21_08865) 1827087..1827464 + 378 WP_229940765.1 hypothetical protein -
LOE21_RS08870 (LOE21_08870) 1827542..1828057 - 516 WP_224556573.1 hypothetical protein -
LOE21_RS08875 (LOE21_08875) 1828035..1828862 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE21_RS08880 (LOE21_08880) 1828859..1829020 - 162 WP_224556578.1 hypothetical protein -
LOE21_RS08885 (LOE21_08885) 1829020..1829472 - 453 WP_224556581.1 hypothetical protein -
LOE21_RS08890 (LOE21_08890) 1829548..1829718 - 171 WP_224556583.1 hypothetical protein -
LOE21_RS08895 (LOE21_08895) 1829818..1830006 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE21_RS08900 (LOE21_08900) 1830118..1830372 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE21_RS08905 (LOE21_08905) 1830369..1830698 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE21_RS08910 (LOE21_08910) 1830759..1831022 + 264 WP_224556602.1 hypothetical protein -
LOE21_RS08915 (LOE21_08915) 1831124..1831414 - 291 WP_224556604.1 hypothetical protein -
LOE21_RS08920 (LOE21_08920) 1831477..1832001 - 525 WP_224556606.1 hypothetical protein -
LOE21_RS08925 (LOE21_08925) 1832221..1833144 - 924 WP_229940510.1 phage minor head protein -
LOE21_RS08930 (LOE21_08930) 1833266..1833430 - 165 WP_229940508.1 hypothetical protein -
LOE21_RS08935 (LOE21_08935) 1833427..1833843 - 417 WP_229940505.1 hypothetical protein -
LOE21_RS08940 (LOE21_08940) 1833840..1834145 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE21_RS08945 (LOE21_08945) 1834142..1834396 - 255 WP_224556623.1 hypothetical protein -
LOE21_RS08950 (LOE21_08950) 1834393..1834551 - 159 WP_224556625.1 hypothetical protein -
LOE21_RS08955 (LOE21_08955) 1834548..1834736 - 189 WP_224556628.1 hypothetical protein -
LOE21_RS08960 (LOE21_08960) 1834736..1835626 - 891 WP_229940766.1 RNA ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1816282..1849939 33657


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224548 WP_224556587.1 NZ_CP086886:1830118-1830372 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224548 NZ_CP120345:854956-855369 [Salmonella enterica subsp. enterica serovar Muenchen]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTAATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGTTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224548 WP_224556600.1 NZ_CP086886:1830369-1830698 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224548 NZ_CP120345:854709-854975 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References