Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 90586..91198 Replicon plasmid P3
Accession NZ_CP086880
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-89

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE22_RS21290 Protein ID WP_028288627.1
Coordinates 90586..90981 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE22_RS21295 Protein ID WP_009503866.1
Coordinates 90971..91198 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE22_RS21270 (LOE22_21260) 87105..87716 - 612 WP_197919471.1 SMC-Scp complex subunit ScpB -
LOE22_RS21275 (LOE22_21265) 87764..88648 - 885 WP_037239259.1 DUF1403 family protein -
LOE22_RS21280 (LOE22_21270) 88775..89914 + 1140 WP_229940649.1 tyrosine-type recombinase/integrase -
LOE22_RS21285 (LOE22_21275) 90016..90507 + 492 Protein_92 recombinase family protein -
LOE22_RS21290 (LOE22_21280) 90586..90981 - 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE22_RS21295 (LOE22_21285) 90971..91198 - 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE22_RS21300 (LOE22_21290) 91407..92600 + 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE22_RS21305 (LOE22_21295) 92584..93516 + 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE22_RS21310 (LOE22_21300) 93730..94941 + 1212 WP_050525470.1 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110569 110569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224545 WP_028288627.1 NZ_CP086880:c90981-90586 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224545 NZ_CP120344:c49045-48629 [Salmonella enterica subsp. enterica serovar Paratyphi B]
GTGAAGAAAATGTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCCGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATTGTGGTCTCGGCCATCACCTACTCAGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGTCACATTGAACTGGTTGACGCGTTCTGCGCCCGCCTCGATGCTATCCTGCCCTGGGACCGGGCC
GCGGTGAACGCCACCACGGAGATTAAGGTGGCGCTACGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCTATTGCCGCCGGCGCGGTACTGGTGACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTTGTTCTGG
AAGACTGGGGAAGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224545 WP_009503866.1 NZ_CP086880:c91198-90971 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224545 NZ_CP120344:c49272-49042 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGATGGAGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGGCTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References