Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2016137..2016717 Replicon chromosome
Accession NZ_CP086877
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-89

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE22_RS10305 Protein ID WP_224556587.1
Coordinates 2016463..2016717 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE22_RS10300 Protein ID WP_224556600.1
Coordinates 2016137..2016466 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE22_RS10245 (LOE22_10260) 2011212..2012099 + 888 WP_224556631.1 RNA ligase family protein -
LOE22_RS10250 (LOE22_10265) 2012099..2012287 + 189 WP_224556628.1 hypothetical protein -
LOE22_RS10255 (LOE22_10270) 2012284..2012442 + 159 WP_224556625.1 hypothetical protein -
LOE22_RS10260 (LOE22_10275) 2012439..2012693 + 255 WP_224556623.1 hypothetical protein -
LOE22_RS10265 (LOE22_10280) 2012690..2012995 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE22_RS10270 (LOE22_10285) 2012992..2013408 + 417 WP_229940505.1 hypothetical protein -
LOE22_RS10275 (LOE22_10290) 2013405..2013569 + 165 WP_229940508.1 hypothetical protein -
LOE22_RS10280 (LOE22_10295) 2013691..2014614 + 924 WP_229940510.1 phage minor head protein -
LOE22_RS10285 (LOE22_10300) 2014834..2015358 + 525 WP_224556606.1 hypothetical protein -
LOE22_RS10290 (LOE22_10305) 2015421..2015711 + 291 WP_224556604.1 hypothetical protein -
LOE22_RS10295 (LOE22_10310) 2015813..2016076 - 264 WP_224556602.1 hypothetical protein -
LOE22_RS10300 (LOE22_10315) 2016137..2016466 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE22_RS10305 (LOE22_10320) 2016463..2016717 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE22_RS10310 (LOE22_10325) 2016829..2017017 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE22_RS10315 (LOE22_10330) 2017117..2017287 + 171 WP_224556583.1 hypothetical protein -
LOE22_RS10320 (LOE22_10335) 2017363..2017815 + 453 WP_224556581.1 hypothetical protein -
LOE22_RS10325 (LOE22_10340) 2017815..2017976 + 162 WP_224556578.1 hypothetical protein -
LOE22_RS10330 (LOE22_10345) 2017973..2018800 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE22_RS10335 (LOE22_10350) 2018778..2019293 + 516 WP_224556573.1 hypothetical protein -
LOE22_RS10340 (LOE22_10355) 2019371..2019748 - 378 WP_229940765.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1999553..2034195 34642


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224542 WP_224556587.1 NZ_CP086877:c2016717-2016463 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224542 NZ_CP120343:4667734-4668045 [Salmonella enterica subsp. enterica serovar Paratyphi B]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224542 WP_224556600.1 NZ_CP086877:c2016466-2016137 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224542 NZ_CP120343:4668042-4668488 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAATCACTCAAC
CAACACCTGGAGAAAACACCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References