Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 26518..27192 Replicon plasmid P6
Accession NZ_CP086876
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-97

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE23_RS23100 Protein ID WP_224557924.1
Coordinates 26770..27192 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE23_RS23095 Protein ID WP_229939240.1
Coordinates 26518..26766 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE23_RS23075 (LOE23_23045) 22431..23075 + 645 WP_224557929.1 type IV secretion system protein -
LOE23_RS23080 (LOE23_23050) 23079..23810 + 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE23_RS23085 (LOE23_23055) 23813..25270 + 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE23_RS23090 (LOE23_23060) 25381..26370 + 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE23_RS23095 (LOE23_23065) 26518..26766 + 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE23_RS23100 (LOE23_23070) 26770..27192 + 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE23_RS23105 (LOE23_23075) 27189..29939 + 2751 WP_224557923.1 lactate dehydrogenase -
LOE23_RS23110 (LOE23_23080) 29936..30994 + 1059 WP_224557922.1 HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..157666 157666


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224540 WP_224557924.1 NZ_CP086876:26770-27192 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224540 NZ_CP120343:c4216812-4216528 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224540 WP_229939240.1 NZ_CP086876:26518-26766 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224540 NZ_CP120343:c4217044-4216802 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References