Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 90585..91197 Replicon plasmid P4
Accession NZ_CP086874
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-97

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE23_RS21885 Protein ID WP_028288627.1
Coordinates 90585..90980 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE23_RS21890 Protein ID WP_009503866.1
Coordinates 90970..91197 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE23_RS21865 (LOE23_21840) 87104..87715 - 612 WP_197919471.1 SMC-Scp complex subunit ScpB -
LOE23_RS21870 (LOE23_21845) 87763..88647 - 885 WP_037239259.1 DUF1403 family protein -
LOE23_RS21875 (LOE23_21850) 88774..89913 + 1140 WP_229940649.1 tyrosine-type recombinase/integrase -
LOE23_RS21880 (LOE23_21855) 90015..90506 + 492 Protein_92 recombinase family protein -
LOE23_RS21885 (LOE23_21860) 90585..90980 - 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE23_RS21890 (LOE23_21865) 90970..91197 - 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE23_RS21895 (LOE23_21870) 91406..92599 + 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE23_RS21900 (LOE23_21875) 92583..93515 + 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE23_RS21905 (LOE23_21880) 93729..94940 + 1212 WP_050525470.1 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110569 110569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224539 WP_028288627.1 NZ_CP086874:c90980-90585 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224539 NZ_CP120343:c4165963-4165625 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGAAAATCCTTTCTGCAAATCAGCGGGTGGCGAAGCCATGCCCGCCGCCTGTACTTGTCTGGCAAACGCTACTGACACG
CCTGCTGGAGCAACACTATGGCCTGTCGCTGAACGATACGCCGTTCAGTGATGAAACGGTTATTCAGGAGCATATCAACG
CCGGTATCACGCTGGCGGATGCAGTTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTTAAC
TGTCAGGAACAGTCGCCTTACCTTCGGGCGGTTGATATTTTACGGGCGCGACAGGCTACTGGTCTGTTGCGGCAAAACCA
GCTTCCTTCGACACGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224539 WP_009503866.1 NZ_CP086874:c91197-90970 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224539 NZ_CP120343:c4166317-4165988 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGGATAAAGAAACCGACACAGTACAGTGGGGACTCAACCGACCTGGTTCTCCTCAATTTAGCGCACGCCTGGTACAAGA
AGGCAAACGCCTACATTATTTAGCTGACCGCGCCGGGATAACAGGCGCTTTCAATGAAGAAGAGTGTCACCAACTGAATG
CCGCATTTCCGCACTTCGTAAAACAAATGGAGCTGATGCTGCTCTCTGGTGAGCTTAACCCCCGCCATGCATATCGCGTA
ACGCTGTACCACAACGAACTGACCTGTGAAGCAGATACGCTCGGTAGCTGTGGCTACGTTTATATAGCGATTTATCCCAC
TCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References