Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 3802429..3802894 Replicon chromosome
Accession NZ_CP086870
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-97

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE23_RS19035 Protein ID WP_224557762.1
Coordinates 3802429..3802692 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE23_RS19040 Protein ID WP_224557764.1
Coordinates 3802679..3802894 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE23_RS19010 (LOE23_19000) 3798145..3799695 - 1551 WP_224557015.1 restriction endonuclease subunit S -
LOE23_RS19015 (LOE23_19005) 3799692..3799988 - 297 WP_224557153.1 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -
LOE23_RS19020 (LOE23_19010) 3799882..3800370 - 489 WP_229938596.1 DEAD/DEAH box helicase family protein -
LOE23_RS19025 (LOE23_19015) 3800596..3801705 - 1110 WP_224558030.1 IS110 family transposase -
LOE23_RS19030 (LOE23_19020) 3801798..3802241 - 444 WP_224557760.1 hypothetical protein -
LOE23_RS19035 (LOE23_19025) 3802429..3802692 + 264 WP_224557762.1 BrnT family toxin Toxin
LOE23_RS19040 (LOE23_19030) 3802679..3802894 + 216 WP_224557764.1 CopG family antitoxin Antitoxin
LOE23_RS19045 (LOE23_19035) 3803247..3803471 - 225 WP_224557765.1 hypothetical protein -
LOE23_RS19050 (LOE23_19040) 3803639..3804019 - 381 WP_224557766.1 helix-turn-helix domain-containing protein -
LOE23_RS19055 (LOE23_19045) 3804200..3805171 - 972 WP_224557767.1 hypothetical protein -
LOE23_RS19060 (LOE23_19050) 3805164..3806348 - 1185 WP_224557768.1 site-specific integrase -
LOE23_RS19070 (LOE23_19060) 3806726..3807424 - 699 WP_037931342.1 SURF1 family protein -
LOE23_RS19075 (LOE23_19065) 3807421..3807786 - 366 WP_028957811.1 cytochrome o ubiquinol oxidase subunit IV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3794048..3806348 12300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10254.52 Da        Isoelectric Point: 5.6550

>T224536 WP_224557762.1 NZ_CP086870:3802429-3802692 [Pseudosulfitobacter pseudonitzschiae]
MKFEYDPDKSAGNKAKHGIDFDEAQALWEDPWLLEAPARTDDEPRFFAIGMIKERHWSAVCTYRGDIIRIISVRRARKQE
IEHYEST

Download         Length: 264 bp

>T224536 NZ_CP120343:2101789-2101892 [Salmonella enterica subsp. enterica serovar Paratyphi B]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8265.40 Da        Isoelectric Point: 10.6538

>AT224536 WP_224557764.1 NZ_CP086870:3802679-3802894 [Pseudosulfitobacter pseudonitzschiae]
MKAREFDQKFDTGENVSDLVDWSKARRTNTQTKRVNVDFPSWVVSGLDQKAKQLGVTRQSLIKLWIAERLQ

Download         Length: 216 bp

>AT224536 NZ_CP120343:c2101894-2101749 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References