Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1823922..1824502 Replicon chromosome
Accession NZ_CP086870
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-97

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE23_RS08900 Protein ID WP_224556587.1
Coordinates 1823922..1824176 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE23_RS08905 Protein ID WP_224556600.1
Coordinates 1824173..1824502 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE23_RS08865 (LOE23_08860) 1820945..1821268 + 324 WP_224556571.1 hypothetical protein -
LOE23_RS08870 (LOE23_08865) 1821346..1821861 - 516 WP_224556573.1 hypothetical protein -
LOE23_RS08875 (LOE23_08870) 1821839..1822666 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE23_RS08880 (LOE23_08875) 1822663..1822824 - 162 WP_224556578.1 hypothetical protein -
LOE23_RS08885 (LOE23_08880) 1822824..1823276 - 453 WP_224556581.1 hypothetical protein -
LOE23_RS08890 (LOE23_08885) 1823352..1823522 - 171 WP_224556583.1 hypothetical protein -
LOE23_RS08895 (LOE23_08890) 1823622..1823810 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE23_RS08900 (LOE23_08895) 1823922..1824176 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE23_RS08905 (LOE23_08900) 1824173..1824502 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE23_RS08910 (LOE23_08905) 1824563..1824826 + 264 WP_224556602.1 hypothetical protein -
LOE23_RS23745 1824813..1824935 - 123 WP_263481010.1 hypothetical protein -
LOE23_RS08915 (LOE23_08910) 1824928..1825218 - 291 WP_224556604.1 hypothetical protein -
LOE23_RS08920 (LOE23_08915) 1825281..1825805 - 525 WP_224556606.1 hypothetical protein -
LOE23_RS08925 (LOE23_08920) 1826025..1826948 - 924 WP_229940510.1 phage minor head protein -
LOE23_RS08930 (LOE23_08925) 1827070..1827234 - 165 WP_229940508.1 hypothetical protein -
LOE23_RS08935 (LOE23_08930) 1827231..1827647 - 417 WP_229940505.1 hypothetical protein -
LOE23_RS08940 (LOE23_08935) 1827644..1827949 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE23_RS08945 (LOE23_08940) 1827946..1828200 - 255 WP_224556623.1 hypothetical protein -
LOE23_RS08950 (LOE23_08945) 1828197..1828355 - 159 WP_224556625.1 hypothetical protein -
LOE23_RS08955 (LOE23_08950) 1828352..1828540 - 189 WP_224556628.1 hypothetical protein -
LOE23_RS08960 (LOE23_08955) 1828540..1829427 - 888 WP_224556631.1 RNA ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1810086..1843743 33657


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224535 WP_224556587.1 NZ_CP086870:1823922-1824176 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224535 NZ_CP120343:c1017839-1017312 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224535 WP_224556600.1 NZ_CP086870:1824173-1824502 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224535 NZ_CP120343:c1018126-1017836 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References