Detailed information of TA system TA224534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 15604..16165
• Replicon: plasmid P5
• Accession: NZ_CP086867
• Organism: Pseudosulfitobacter pseudonitzschiae strain SC33-17

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOE29_RS23000
• Protein ID: WP_224557555.1
• Coordinates: 15604..15879 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOE29_RS23005
• Protein ID: WP_224557554.1
• Coordinates: 15872..16165 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOE29_RS22985 (LOE29_22965)	11393..12709	-	1317	WP_224557560.1	lactate racemase domain-containing protein	-
LOE29_RS22990 (LOE29_22970)	12726..14273	-	1548	WP_224557559.1	altronate dehydratase family protein	-
LOE29_RS22995 (LOE29_22975)	14365..15135	+	771	WP_224557557.1	GntR family transcriptional regulator	-
LOE29_RS23000 (LOE29_22980)	15604..15879	-	276	WP_224557555.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOE29_RS23005 (LOE29_22985)	15872..16165	-	294	WP_224557554.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOE29_RS23010 (LOE29_22990)	16236..17141	-	906	WP_224557552.1	dihydrodipicolinate synthase family protein	-
LOE29_RS23015 (LOE29_22995)	17152..18891	-	1740	WP_224557550.1	L-arabinonate dehydratase	-
LOE29_RS23020 (LOE29_23000)	19153..20688	+	1536	WP_224557548.1	aldehyde dehydrogenase (NADP(+))	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..82231	82231

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-55)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10108.67 Da
• Isoelectric Point: 4.4912

>T224534 WP_224557555.1 NZ_CP086867:c15879-15604 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Nucleotide

• Length: 276 bp

>T224534 NZ_CP120343:854958-855371 [Salmonella enterica subsp. enterica serovar Paratyphi B]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTAATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGTTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10166.59 Da
• Isoelectric Point: 7.2024

>AT224534 WP_224557554.1 NZ_CP086867:c16165-15872 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Nucleotide

• Length: 294 bp

>AT224534 NZ_CP120343:854711-854977 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA