Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 27624..28236 Replicon plasmid P4
Accession NZ_CP086866
Organism Pseudosulfitobacter pseudonitzschiae strain SC33-17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE29_RS22500 Protein ID WP_028288627.1
Coordinates 27624..28019 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE29_RS22505 Protein ID WP_009503866.1
Coordinates 28009..28236 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE29_RS22480 (LOE29_22460) 24143..24754 - 612 WP_197919471.1 SMC-Scp complex subunit ScpB -
LOE29_RS22485 (LOE29_22465) 24802..25686 - 885 WP_037239259.1 DUF1403 family protein -
LOE29_RS22490 (LOE29_22470) 25813..26952 + 1140 WP_229940649.1 tyrosine-type recombinase/integrase -
LOE29_RS22495 (LOE29_22475) 27054..27545 + 492 Protein_27 recombinase family protein -
LOE29_RS22500 (LOE29_22480) 27624..28019 - 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE29_RS22505 (LOE29_22485) 28009..28236 - 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE29_RS22510 (LOE29_22490) 28445..29638 + 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE29_RS22515 (LOE29_22495) 29622..30554 + 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE29_RS22520 (LOE29_22500) 30768..31979 + 1212 WP_050525470.1 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110568 110568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224533 WP_028288627.1 NZ_CP086866:c28019-27624 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224533 NZ_CP120343:311879-312247 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224533 WP_009503866.1 NZ_CP086866:c28236-28009 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224533 NZ_CP120343:311661-311882 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References