Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 97818..98492 Replicon plasmid P1
Accession NZ_CP086863
Organism Pseudosulfitobacter pseudonitzschiae strain SC33-17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE29_RS19565 Protein ID WP_224557924.1
Coordinates 98070..98492 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE29_RS19560 Protein ID WP_229939240.1
Coordinates 97818..98066 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE29_RS19540 (LOE29_19535) 93731..94375 + 645 WP_224557929.1 type IV secretion system protein -
LOE29_RS19545 (LOE29_19540) 94379..95110 + 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE29_RS19550 (LOE29_19545) 95113..96570 + 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE29_RS19555 (LOE29_19550) 96681..97670 + 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE29_RS19560 (LOE29_19555) 97818..98066 + 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE29_RS19565 (LOE29_19560) 98070..98492 + 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE29_RS19570 (LOE29_19565) 98489..101239 + 2751 WP_224557923.1 lactate dehydrogenase -
LOE29_RS19575 (LOE29_19570) 101236..102294 + 1059 WP_224557922.1 HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..290598 290598


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224530 WP_224557924.1 NZ_CP086863:98070-98492 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224530 NZ_CP120341:c4488496-4488122 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAGAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAGCGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224530 WP_229939240.1 NZ_CP086863:97818-98066 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224530 NZ_CP120341:c4488738-4488496 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References