Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 93515..94127 Replicon plasmid P4
Accession NZ_CP086858
Organism Pseudosulfitobacter pseudonitzschiae strain SC33-25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE30_RS23340 Protein ID WP_028288627.1
Coordinates 93732..94127 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE30_RS23335 Protein ID WP_009503866.1
Coordinates 93515..93742 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE30_RS23320 (LOE30_23315) 89772..90983 - 1212 WP_050525470.1 plasmid replication protein RepC -
LOE30_RS23325 (LOE30_23320) 91197..92129 - 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE30_RS23330 (LOE30_23325) 92113..93306 - 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE30_RS23335 (LOE30_23330) 93515..93742 + 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE30_RS23340 (LOE30_23335) 93732..94127 + 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE30_RS23345 (LOE30_23340) 94206..94697 - 492 Protein_98 recombinase family protein -
LOE30_RS23350 (LOE30_23345) 94799..95950 - 1152 WP_224557873.1 tyrosine-type recombinase/integrase -
LOE30_RS23355 (LOE30_23350) 96065..96949 + 885 WP_037239259.1 DUF1403 family protein -
LOE30_RS23360 (LOE30_23355) 96997..97608 + 612 WP_197919471.1 SMC-Scp complex subunit ScpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110565 110565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224527 WP_028288627.1 NZ_CP086858:93732-94127 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224527 NZ_CP120341:c2353423-2353139 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTACGGAAACGGCTCGAAAACCCTCGGGTTCCTGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGGCACAGAAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224527 WP_009503866.1 NZ_CP086858:93515-93742 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224527 NZ_CP120341:c2353661-2353413 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References