Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 277704..278378 Replicon plasmid P2
Accession NZ_CP086856
Organism Pseudosulfitobacter pseudonitzschiae strain SC33-25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE30_RS21850 Protein ID WP_224557924.1
Coordinates 277704..278126 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE30_RS21855 Protein ID WP_229939240.1
Coordinates 278130..278378 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE30_RS21840 (LOE30_21835) 273902..274960 - 1059 WP_224557922.1 HEPN domain-containing protein -
LOE30_RS21845 (LOE30_21840) 274957..277707 - 2751 WP_224557923.1 lactate dehydrogenase -
LOE30_RS21850 (LOE30_21845) 277704..278126 - 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE30_RS21855 (LOE30_21850) 278130..278378 - 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE30_RS21860 (LOE30_21855) 278526..279515 - 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE30_RS21865 (LOE30_21860) 279626..281083 - 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE30_RS21870 (LOE30_21865) 281086..281817 - 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE30_RS21875 (LOE30_21870) 281821..282465 - 645 WP_224557929.1 type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..290594 290594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224526 WP_224557924.1 NZ_CP086856:c278126-277704 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224526 NZ_CP120341:1983453-1983555 [Salmonella enterica subsp. enterica serovar Muenchen]
GCCAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224526 WP_229939240.1 NZ_CP086856:c278378-278130 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224526 NZ_CP120341:c1983557-1983414 [Salmonella enterica subsp. enterica serovar Muenchen]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTGGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References