Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1683159..1683739 Replicon chromosome
Accession NZ_CP086854
Organism Pseudosulfitobacter pseudonitzschiae strain SC33-25

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE30_RS08280 Protein ID WP_224556587.1
Coordinates 1683159..1683413 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE30_RS08285 Protein ID WP_224556600.1
Coordinates 1683410..1683739 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE30_RS08245 (LOE30_08240) 1680182..1680505 + 324 WP_224556571.1 hypothetical protein -
LOE30_RS08250 (LOE30_08245) 1680583..1681098 - 516 WP_224556573.1 hypothetical protein -
LOE30_RS08255 (LOE30_08250) 1681076..1681903 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE30_RS08260 (LOE30_08255) 1681900..1682061 - 162 WP_224556578.1 hypothetical protein -
LOE30_RS08265 (LOE30_08260) 1682061..1682513 - 453 WP_224556581.1 hypothetical protein -
LOE30_RS08270 (LOE30_08265) 1682589..1682759 - 171 WP_224556583.1 hypothetical protein -
LOE30_RS08275 (LOE30_08270) 1682859..1683047 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE30_RS08280 (LOE30_08275) 1683159..1683413 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE30_RS08285 (LOE30_08280) 1683410..1683739 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE30_RS08290 (LOE30_08285) 1683800..1684063 + 264 WP_224556602.1 hypothetical protein -
LOE30_RS24705 1684050..1684172 - 123 WP_263481010.1 hypothetical protein -
LOE30_RS08295 (LOE30_08290) 1684165..1684455 - 291 WP_224556604.1 hypothetical protein -
LOE30_RS08300 (LOE30_08295) 1684518..1685042 - 525 WP_224556606.1 hypothetical protein -
LOE30_RS08305 (LOE30_08300) 1685262..1685759 - 498 WP_229994453.1 phage minor head protein -
LOE30_RS08310 (LOE30_08305) 1685965..1686129 - 165 WP_229940508.1 hypothetical protein -
LOE30_RS08315 (LOE30_08310) 1686126..1686542 - 417 WP_229940505.1 hypothetical protein -
LOE30_RS08320 (LOE30_08315) 1686539..1686844 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE30_RS08325 (LOE30_08320) 1686841..1687095 - 255 WP_224556623.1 hypothetical protein -
LOE30_RS08330 (LOE30_08325) 1687092..1687250 - 159 WP_224556625.1 hypothetical protein -
LOE30_RS08335 (LOE30_08330) 1687247..1687435 - 189 WP_224556628.1 hypothetical protein -
LOE30_RS08340 (LOE30_08335) 1687435..1688325 - 891 WP_229940766.1 RNA ligase family protein -
LOE30_RS08345 (LOE30_08340) 1688322..1688735 - 414 WP_229996253.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1665467..1702638 37171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224522 WP_224556587.1 NZ_CP086854:1683159-1683413 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224522 NZ_CP120341:206118-206603 [Salmonella enterica subsp. enterica serovar Muenchen]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTCGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGCCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224522 WP_224556600.1 NZ_CP086854:1683410-1683739 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224522 NZ_CP120341:205843-206130 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References