Detailed information of TA system TA224521

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 67659..68220
• Replicon: plasmid P6
• Accession: NZ_CP086853
• Organism: Pseudosulfitobacter pseudonitzschiae strain SC33-87

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOE31_RS24150
• Protein ID: WP_224557555.1
• Coordinates: 67659..67934 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOE31_RS24155
• Protein ID: WP_224557554.1
• Coordinates: 67927..68220 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOE31_RS24135 (LOE31_24125)	63448..64764	-	1317	WP_224557560.1	lactate racemase domain-containing protein	-
LOE31_RS24140 (LOE31_24130)	64781..66328	-	1548	WP_224557559.1	altronate dehydratase family protein	-
LOE31_RS24145 (LOE31_24135)	66420..67190	+	771	WP_224557557.1	GntR family transcriptional regulator	-
LOE31_RS24150 (LOE31_24140)	67659..67934	-	276	WP_224557555.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOE31_RS24155 (LOE31_24145)	67927..68220	-	294	WP_224557554.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOE31_RS24160 (LOE31_24150)	68291..69196	-	906	WP_224557552.1	dihydrodipicolinate synthase family protein	-
LOE31_RS24165 (LOE31_24155)	69207..70946	-	1740	WP_224557550.1	L-arabinonate dehydratase	-
LOE31_RS24170 (LOE31_24160)	71208..72743	+	1536	WP_224557548.1	aldehyde dehydrogenase (NADP(+))	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..82233	82233

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-55)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10108.67 Da
• Isoelectric Point: 4.4912

>T224521 WP_224557555.1 NZ_CP086853:c67934-67659 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Nucleotide

• Length: 276 bp

>T224521 NZ_CP120340:50117-50422 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTACCGCCTGTTTGTGGATGTGCAGAGCGACATCGTCGATAC
CCCTGGCCGGCGAATGGTGATCCCGCTGGCCAGTGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCGGTGG
TGCATATCGGGGATGAGAGCTGGCGTCTGATGACCACGGATATGGCCAGTGTCCCGGCCTCATTCATCGGGGAAGAGGTG
GCCGAGCTCAGCCACAGGGAGAACGACATCAAAAACGCCATTAACCTGATGTTCTGGGGGATCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10166.59 Da
• Isoelectric Point: 7.2024

>AT224521 WP_224557554.1 NZ_CP086853:c68220-67927 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Nucleotide

• Length: 294 bp

>AT224521 NZ_CP120340:49897-50115 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAAGCAGCGTATTACTGTCACCATAGACAGTGACAGCTATCAGTTACTCAAGTCCGCAGACGTGAATATCTCCGGCCT
GGTAAATACTGCCATGCAGAAGGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAGCGAACGGCTCCTTTGCAGACGAAAACAGGGACTGGTGA