Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2510309..2510889 Replicon chromosome
Accession NZ_CP086847
Organism Pseudosulfitobacter pseudonitzschiae strain SC33-87

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE31_RS12560 Protein ID WP_224556587.1
Coordinates 2510635..2510889 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE31_RS12555 Protein ID WP_224556600.1
Coordinates 2510309..2510638 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE31_RS12500 (LOE31_12500) 2505381..2506271 + 891 WP_229940766.1 RNA ligase family protein -
LOE31_RS12505 (LOE31_12505) 2506271..2506459 + 189 WP_224556628.1 hypothetical protein -
LOE31_RS12510 (LOE31_12510) 2506456..2506614 + 159 WP_224556625.1 hypothetical protein -
LOE31_RS12515 (LOE31_12515) 2506611..2506865 + 255 WP_224556623.1 hypothetical protein -
LOE31_RS12520 (LOE31_12520) 2506862..2507167 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE31_RS12525 (LOE31_12525) 2507164..2507580 + 417 WP_229940505.1 hypothetical protein -
LOE31_RS12530 (LOE31_12530) 2507577..2507741 + 165 WP_229940508.1 hypothetical protein -
LOE31_RS12535 (LOE31_12535) 2507863..2508786 + 924 WP_229940510.1 phage minor head protein -
LOE31_RS12540 (LOE31_12540) 2509006..2509530 + 525 WP_224556606.1 hypothetical protein -
LOE31_RS12545 (LOE31_12545) 2509593..2509883 + 291 WP_224556604.1 hypothetical protein -
LOE31_RS24235 2509876..2509998 + 123 WP_263481010.1 hypothetical protein -
LOE31_RS12550 (LOE31_12550) 2509985..2510248 - 264 WP_224556602.1 hypothetical protein -
LOE31_RS12555 (LOE31_12555) 2510309..2510638 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE31_RS12560 (LOE31_12560) 2510635..2510889 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE31_RS12565 (LOE31_12565) 2511001..2511189 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE31_RS12570 (LOE31_12570) 2511289..2511459 + 171 WP_224556583.1 hypothetical protein -
LOE31_RS12575 (LOE31_12575) 2511535..2511987 + 453 WP_224556581.1 hypothetical protein -
LOE31_RS12580 (LOE31_12580) 2511987..2512148 + 162 WP_224556578.1 hypothetical protein -
LOE31_RS12585 (LOE31_12585) 2512145..2512972 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE31_RS12590 (LOE31_12590) 2512950..2513465 + 516 WP_224556573.1 hypothetical protein -
LOE31_RS12595 (LOE31_12595) 2513543..2513866 - 324 WP_224556571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2492508..2529129 36621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224516 WP_224556587.1 NZ_CP086847:c2510889-2510635 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224516 NZ_CP120339:c4666523-4666212 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224516 WP_224556600.1 NZ_CP086847:c2510638-2510309 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224516 NZ_CP120339:c4666211-4665921 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References