Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 90997..91609 Replicon plasmid P4
Accession NZ_CP086843
Organism Pseudosulfitobacter pseudonitzschiae strain TC12-31

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE24_RS23465 Protein ID WP_028288627.1
Coordinates 90997..91392 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE24_RS23470 Protein ID WP_009503866.1
Coordinates 91382..91609 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE24_RS23445 (LOE24_23410) 87514..88125 - 612 WP_197919471.1 SMC-Scp complex subunit ScpB -
LOE24_RS23450 (LOE24_23415) 88173..89057 - 885 WP_037239259.1 DUF1403 family protein -
LOE24_RS23455 (LOE24_23420) 89186..90325 + 1140 WP_229940649.1 tyrosine-type recombinase/integrase -
LOE24_RS23460 (LOE24_23425) 90427..90918 + 492 Protein_93 recombinase family protein -
LOE24_RS23465 (LOE24_23430) 90997..91392 - 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE24_RS23470 (LOE24_23435) 91382..91609 - 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE24_RS23475 (LOE24_23440) 91818..93011 + 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE24_RS23480 (LOE24_23445) 92995..93927 + 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE24_RS23485 (LOE24_23450) 94141..95352 + 1212 WP_050525470.1 plasmid replication protein RepC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..110569 110569


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224513 WP_028288627.1 NZ_CP086843:c91392-90997 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224513 NZ_CP120339:3522087-3522305 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224513 WP_009503866.1 NZ_CP086843:c91609-91382 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224513 NZ_CP120339:3521685-3522059 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References