Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 378367..378947 Replicon chromosome
Accession NZ_CP086839
Organism Pseudosulfitobacter pseudonitzschiae strain TC12-31

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE24_RS01975 Protein ID WP_224556587.1
Coordinates 378693..378947 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE24_RS01970 Protein ID WP_224556600.1
Coordinates 378367..378696 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE24_RS01915 (LOE24_01910) 373442..374329 + 888 WP_224556631.1 RNA ligase family protein -
LOE24_RS01920 (LOE24_01915) 374329..374517 + 189 WP_224556628.1 hypothetical protein -
LOE24_RS01925 (LOE24_01920) 374514..374672 + 159 WP_224556625.1 hypothetical protein -
LOE24_RS01930 (LOE24_01925) 374669..374923 + 255 WP_224556623.1 hypothetical protein -
LOE24_RS01935 (LOE24_01930) 374920..375225 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE24_RS01940 (LOE24_01935) 375222..375638 + 417 WP_229940505.1 hypothetical protein -
LOE24_RS01945 (LOE24_01940) 375635..375799 + 165 WP_229940508.1 hypothetical protein -
LOE24_RS01950 (LOE24_01945) 375921..376844 + 924 WP_229940510.1 phage minor head protein -
LOE24_RS01955 (LOE24_01950) 377064..377588 + 525 WP_224556606.1 hypothetical protein -
LOE24_RS01960 (LOE24_01955) 377651..377941 + 291 WP_224556604.1 hypothetical protein -
LOE24_RS24825 377934..378056 + 123 WP_263481010.1 hypothetical protein -
LOE24_RS01965 (LOE24_01960) 378043..378306 - 264 WP_224556602.1 hypothetical protein -
LOE24_RS01970 (LOE24_01965) 378367..378696 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE24_RS01975 (LOE24_01970) 378693..378947 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE24_RS01980 (LOE24_01975) 379059..379247 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE24_RS01985 (LOE24_01980) 379347..379517 + 171 WP_224556583.1 hypothetical protein -
LOE24_RS01990 (LOE24_01985) 379593..380045 + 453 WP_224556581.1 hypothetical protein -
LOE24_RS01995 (LOE24_01990) 380045..380206 + 162 WP_224556578.1 hypothetical protein -
LOE24_RS02000 (LOE24_01995) 380203..381030 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE24_RS02005 (LOE24_02000) 381008..381523 + 516 WP_224556573.1 hypothetical protein -
LOE24_RS02010 (LOE24_02005) 381601..381924 - 324 WP_224556571.1 hypothetical protein -
LOE24_RS02015 382139..382681 - 543 WP_229940519.1 hypothetical protein -
LOE24_RS02020 383244..383492 - 249 WP_229940863.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 360566..397187 36621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224509 WP_224556587.1 NZ_CP086839:c378947-378693 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224509 NZ_CP120339:311879-312247 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224509 WP_224556600.1 NZ_CP086839:c378696-378367 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224509 NZ_CP120339:311661-311882 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References