Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 3303600..3304065 Replicon chromosome
Accession NZ_CP086832
Organism Pseudosulfitobacter pseudonitzschiae strain TC12-33

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE25_RS16695 Protein ID WP_224557762.1
Coordinates 3303600..3303863 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LOE25_RS16700 Protein ID WP_224557764.1
Coordinates 3303850..3304065 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE25_RS16670 (LOE25_16655) 3299316..3300866 - 1551 WP_224557015.1 restriction endonuclease subunit S -
LOE25_RS16675 (LOE25_16660) 3300863..3301159 - 297 WP_224557153.1 type I restriction-modification enzyme R subunit C-terminal domain-containing protein -
LOE25_RS16680 (LOE25_16665) 3301053..3301541 - 489 WP_229938596.1 DEAD/DEAH box helicase family protein -
LOE25_RS16685 (LOE25_16670) 3301767..3302876 - 1110 WP_224558030.1 IS110 family transposase -
LOE25_RS16690 (LOE25_16675) 3302969..3303412 - 444 WP_224557760.1 hypothetical protein -
LOE25_RS16695 (LOE25_16680) 3303600..3303863 + 264 WP_224557762.1 BrnT family toxin Toxin
LOE25_RS16700 (LOE25_16685) 3303850..3304065 + 216 WP_224557764.1 CopG family antitoxin Antitoxin
LOE25_RS16705 (LOE25_16690) 3304418..3304642 - 225 WP_224557765.1 hypothetical protein -
LOE25_RS16710 (LOE25_16695) 3304810..3305190 - 381 WP_224557766.1 helix-turn-helix domain-containing protein -
LOE25_RS16715 (LOE25_16700) 3305371..3306342 - 972 WP_224557767.1 hypothetical protein -
LOE25_RS16720 (LOE25_16705) 3306335..3307519 - 1185 WP_224557768.1 site-specific integrase -
LOE25_RS16730 (LOE25_16715) 3307897..3308595 - 699 WP_037931342.1 SURF1 family protein -
LOE25_RS16735 (LOE25_16720) 3308592..3308957 - 366 WP_028957811.1 cytochrome o ubiquinol oxidase subunit IV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3295006..3307519 12513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10254.52 Da        Isoelectric Point: 5.6550

>T224504 WP_224557762.1 NZ_CP086832:3303600-3303863 [Pseudosulfitobacter pseudonitzschiae]
MKFEYDPDKSAGNKAKHGIDFDEAQALWEDPWLLEAPARTDDEPRFFAIGMIKERHWSAVCTYRGDIIRIISVRRARKQE
IEHYEST

Download         Length: 264 bp

>T224504 NZ_CP120337:4667743-4668054 [Salmonella enterica subsp. enterica serovar Muenchen]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8265.40 Da        Isoelectric Point: 10.6538

>AT224504 WP_224557764.1 NZ_CP086832:3303850-3304065 [Pseudosulfitobacter pseudonitzschiae]
MKAREFDQKFDTGENVSDLVDWSKARRTNTQTKRVNVDFPSWVVSGLDQKAKQLGVTRQSLIKLWIAERLQ

Download         Length: 216 bp

>AT224504 NZ_CP120337:4668051-4668497 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAATCACTCAAC
CAACACCTGGAGAAAACACCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References